Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1352749..1353308 Replicon chromosome
Accession NZ_CP082317
Organism Vibrio alginolyticus strain SXV3

Toxin (Protein)


Gene name relE Uniprot ID A0A347UR22
Locus tag K6754_RS06575 Protein ID WP_005398411.1
Coordinates 1352749..1353027 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR21
Locus tag K6754_RS06580 Protein ID WP_005398409.1
Coordinates 1353024..1353308 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6754_RS06495 (K6754_06475) 1347859..1348092 + 234 WP_053397245.1 hypothetical protein -
K6754_RS06505 (K6754_06485) 1348355..1348621 + 267 WP_238975172.1 hypothetical protein -
K6754_RS06510 (K6754_06490) 1348658..1348747 + 90 WP_196334514.1 DUF3265 domain-containing protein -
K6754_RS06515 (K6754_06495) 1348779..1349234 + 456 WP_238975174.1 hypothetical protein -
K6754_RS06520 (K6754_06500) 1349263..1349352 + 90 WP_078555101.1 DUF3265 domain-containing protein -
K6754_RS06525 (K6754_06505) 1349493..1349972 + 480 WP_054577360.1 type VI secretion system amidase effector protein Tae4 -
K6754_RS06530 (K6754_06510) 1349954..1350319 + 366 WP_054577359.1 T6SS amidase immunity protein Tai4 family protein -
K6754_RS06535 (K6754_06515) 1350334..1350426 + 93 WP_079882880.1 DUF3265 domain-containing protein -
K6754_RS06540 (K6754_06520) 1350454..1351011 + 558 WP_100216247.1 hypothetical protein -
K6754_RS06545 1351002..1351064 + 63 Protein_1208 DUF3265 domain-containing protein -
K6754_RS06550 (K6754_06525) 1351158..1351505 + 348 WP_031780756.1 hypothetical protein -
K6754_RS06555 (K6754_06530) 1351520..1351611 + 92 Protein_1210 DUF3265 domain-containing protein -
K6754_RS06560 (K6754_06535) 1352051..1352143 + 93 WP_079740788.1 DUF3265 domain-containing protein -
K6754_RS06565 1352243..1352463 - 221 Protein_1212 hypothetical protein -
K6754_RS06570 (K6754_06540) 1352631..1352720 + 90 WP_140382132.1 DUF3265 domain-containing protein -
K6754_RS06575 (K6754_06545) 1352749..1353027 - 279 WP_005398411.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
K6754_RS06580 (K6754_06550) 1353024..1353308 - 285 WP_005398409.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K6754_RS06585 1353385..1353476 + 92 Protein_1216 DUF3265 domain-containing protein -
K6754_RS06590 (K6754_06560) 1353621..1353896 + 276 WP_047726024.1 hypothetical protein -
K6754_RS06595 (K6754_06565) 1354109..1354918 + 810 WP_053306503.1 FRG domain-containing protein -
K6754_RS06600 (K6754_06570) 1354939..1355031 + 93 WP_004748931.1 DUF3265 domain-containing protein -
K6754_RS06605 (K6754_06575) 1355076..1356197 + 1122 WP_053306504.1 hypothetical protein -
K6754_RS06610 (K6754_06580) 1356351..1356755 + 405 WP_238951994.1 hydrolase -
K6754_RS06615 (K6754_06585) 1356787..1356879 + 93 WP_077681052.1 DUF3265 domain-containing protein -
K6754_RS06620 (K6754_06590) 1356908..1357306 + 399 WP_238966997.1 DUF6232 family protein -
K6754_RS06625 (K6754_06595) 1357321..1357413 + 93 WP_017821407.1 DUF3265 domain-containing protein -
K6754_RS06630 (K6754_06600) 1357495..1357752 + 258 WP_005448240.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
K6754_RS06635 (K6754_06605) 1357740..1358042 + 303 WP_238966996.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1316682..1376441 59759
- inside Integron - - 1317199..1373707 56508


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10891.57 Da        Isoelectric Point: 4.3430

>T214553 WP_005398411.1 NZ_CP082317:c1353027-1352749 [Vibrio alginolyticus]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD

Download         Length: 279 bp

>T214553 NZ_CP110141:c1145563-1144718 [Streptococcus suis]
ATGAACAAAGCTAAATTAACAGCACTCTGTCATAAAATATCAAAGAATACTGGTTTAACCTTTAATTCCGTGATGACCTA
TTACTTTCTTGAAGTGATTTTGAAAAAATTAAGTCAGAGTACCTATTCAAATCACTATATCTTCAAAGGAGGATTCCTAC
TTTCGAATGTCATCGGAGTTGAATCTCGTAGCACTGTTGATATTGACTTTTTATTCCATCAAATAACACTATCAGAAGAA
ACTGTTAAACAGCAACTTGAAGAAGTTTTAGCAGATTCTGAAAAAGGTATTTCTTTCACAATTCAATCTATCACAGCTAT
AAAAGAAAGTGATGAATATGGTGGCTATCGTGCGACCATTTTGTGCCAACTTGAGAATATTAAACAAGTTATCCATTTGG
ATATTGCGACAGGTGATGTTGTAACTCCTCAGCCGATAACATACGACTATAAAGCTATTTTTGATGAAGACAATTTTCCA
ATCATTGCTTATACAATTGAAACAATTCTAGCTGAGAAACTTCAAACCATCTATTCACGCAACTTCTTGAACAGCAGAAG
CAAAGATTTTTACGATGTTTATATTATTTCAAAACTGAAGAAAGAAGACATTGACTTCATTCAATTGAAAAATGCCTGTC
AGAGAACATTTTCATATCGCGAAACAGAACTCGATTTTGTAAAGATTATTGAACTACTCGAGAGGTTCAAATCTGACCCT
ATTCAGAATAAACAATGGCAAAATTATTCAAAAAAAAATAGCTATACAAAAGGGATTTCACTTGCAGATGTTCTTGATGA
GATGATTCGTCTCATAACAGTTCTCATTTCTATAAATTCTGATTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11069.40 Da        Isoelectric Point: 9.2167

>AT214553 WP_005398409.1 NZ_CP082317:c1353308-1353024 [Vibrio alginolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ

Download         Length: 285 bp

>AT214553 NZ_CP110141:c1146150-1145560 [Streptococcus suis]
ATGTCAAAAAAAGAGATTCTACTCGATTTTATAGAAAAGAACAATGGAATTGTCACAAACAAAGATTGTAAAGCACTAGG
TATTCCAACAATATATCTGACAAGACTAGAGAAAGAAGGCATTATCTTCCGAGTTGAAAAAGGTATTTTCCTAACCCAAA
ACGGAGACTATGATGAATACTACTTCTTTCAATATCGTTTTCCTAAGGCTATTTTCTCTTATATTTCGGCACTGTATCTA
CAACAGTTTACAGATGAAATTCCACAATATTTTGATGTGACAGTTCCTAGAGGCTACCGCTTTAATACTCCTCCAGCTAA
TCTAAATATTCACTTTGTCTCTAAAGAATACAGCGAGCTGGGAATGACTACTGTACCTACTCCTATGGGAAACAACGTAA
GGGTATATGATTTTGAACGTATTATTTGTGATTTTGTAATACATCGAGAAAAGATTGATTCCGAACTCTTTGTCAAGACA
CTTCAATCTTATGGGAACTATCCTAAAAAAAATCTAGCAAAACTCTATGAATATGCGACAAAAATGAATACTTTAGAAAA
AGTTAAACAAACTCTGGAGGTTCTAATATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR22

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR21

References