Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 797590..798247 Replicon chromosome
Accession NZ_CP082290
Organism Klebsiella pneumoniae subsp. pneumoniae strain Kp6

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag K6T93_RS04010 Protein ID WP_002916310.1
Coordinates 797837..798247 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag K6T93_RS04005 Protein ID WP_002916312.1
Coordinates 797590..797856 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6T93_RS03980 (K6T93_03980) 792798..794231 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
K6T93_RS03985 (K6T93_03985) 794350..795078 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
K6T93_RS03990 (K6T93_03990) 795128..795439 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
K6T93_RS03995 (K6T93_03995) 795603..796262 + 660 WP_002916317.1 hemolysin III family protein -
K6T93_RS04000 (K6T93_04000) 796361..797344 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
K6T93_RS04005 (K6T93_04005) 797590..797856 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
K6T93_RS04010 (K6T93_04010) 797837..798247 + 411 WP_002916310.1 protein YgfX Toxin
K6T93_RS04015 (K6T93_04015) 798254..798775 - 522 WP_004144730.1 flavodoxin FldB -
K6T93_RS04020 (K6T93_04020) 798876..799772 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
K6T93_RS04025 (K6T93_04025) 799795..800508 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K6T93_RS04030 (K6T93_04030) 800514..802247 + 1734 WP_196555037.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T214512 WP_002916310.1 NZ_CP082290:797837-798247 [Klebsiella pneumoniae subsp. pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T214512 NZ_CP110118:c135422-135117 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT214512 WP_002916312.1 NZ_CP082290:797590-797856 [Klebsiella pneumoniae subsp. pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT214512 NZ_CP110118:c135642-135424 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References