Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 23900..24630 Replicon chromosome
Accession NZ_CP082280
Organism Enterobacter cancerogenus strain HAEC1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HU826_RS00125 Protein ID WP_058609917.1
Coordinates 23900..24214 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HU826_RS00130 Protein ID WP_127463536.1
Coordinates 24211..24630 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HU826_RS00100 (HU826_00100) 19565..20653 + 1089 WP_058609914.1 cellulase family glycosylhydrolase -
HU826_RS00105 (HU826_00105) 20556..21740 - 1185 WP_006177615.1 multidrug efflux MFS transporter EmrD -
HU826_RS00110 (HU826_00110) 21916..22749 - 834 WP_137273017.1 EamA family transporter -
HU826_RS00115 (HU826_00115) 22812..23258 - 447 WP_222892285.1 GNAT family N-acetyltransferase -
HU826_RS00120 (HU826_00120) 23323..23412 - 90 WP_072208832.1 type I toxin-antitoxin system toxin TisB -
HU826_RS00125 (HU826_00125) 23900..24214 + 315 WP_058609917.1 type II toxin-antitoxin system HigB family toxin Toxin
HU826_RS00130 (HU826_00130) 24211..24630 + 420 WP_127463536.1 helix-turn-helix domain-containing protein Antitoxin
HU826_RS00135 (HU826_00135) 24781..24879 + 99 WP_072208833.1 ilvB operon leader peptide IvbL -
HU826_RS00140 (HU826_00140) 24982..26670 + 1689 WP_153682207.1 acetolactate synthase large subunit -
HU826_RS00145 (HU826_00145) 26674..26961 + 288 WP_006177620.1 acetolactate synthase small subunit -
HU826_RS00150 (HU826_00150) 27061..27654 + 594 WP_006177621.1 transcriptional regulator UhpA -
HU826_RS00155 (HU826_00155) 27651..29156 + 1506 WP_006177622.1 signal transduction histidine-protein kinase/phosphatase UhpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-137)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12426.57 Da        Isoelectric Point: 10.2219

>T214494 WP_058609917.1 NZ_CP082280:23900-24214 [Enterobacter cancerogenus]
MHLISMKAIFDAVTLFPQHKQELLFLGRIIEKSNCPTPDALKKLFPTLDNFKYLDKHYVLDIANNNLRVVALIFFESQKF
YVRHVFTHKEYDRFTEKHRTKGKK

Download         Length: 315 bp

>T214494 NZ_CP110117:1078023-1078358 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15468.97 Da        Isoelectric Point: 4.9192

>AT214494 WP_127463536.1 NZ_CP082280:24211-24630 [Enterobacter cancerogenus]
MMIVADAMKATHALVAAVPLLGEHPNEQDYNDALELVEYLLMNEPGSPLLDIVCARIRHYEANQPEIVALRQEMESVPVG
IAVLRTLIDQYKLTLSDFQDEIGSKSMVSRVLNGQRQLTLTHIKKLAARFGVSPALFIE

Download         Length: 420 bp

>AT214494 NZ_CP110117:1077775-1078023 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References