Detailed information of TA system TA214484

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 1728083..1728721
• Replicon: chromosome
• Accession: NZ_CP082272
• Organism: Pasteurella multocida strain 17BRD-035

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: K7B08_RS08730
• Protein ID: WP_169326243.1
• Coordinates: 1728545..1728721 (-)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: K7B08_RS08725
• Protein ID: WP_108511501.1
• Coordinates: 1728083..1728499 (-)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K7B08_RS08665	1723591..1724016	+	426	WP_223131940.1	recombination protein NinB	-
K7B08_RS08670	1724090..1724290	+	201	WP_064702801.1	hypothetical protein	-
K7B08_RS08675	1724299..1724541	+	243	WP_126417809.1	hypothetical protein	-
K7B08_RS08680	1724538..1724693	+	156	WP_155736201.1	hypothetical protein	-
K7B08_RS08685	1724993..1725199	+	207	WP_064965023.1	hypothetical protein	-
K7B08_RS08690	1725225..1725821	+	597	WP_223131915.1	recombination protein NinG	-
K7B08_RS08695	1725823..1726284	+	462	WP_014391474.1	antiterminator Q family protein	-
K7B08_RS08705	1726611..1726976	+	366	WP_223131916.1	phage holin, lambda family	-
K7B08_RS08710	1726948..1727532	+	585	WP_223131917.1	glycoside hydrolase family 19 protein	-
K7B08_RS08715	1727535..1727858	+	324	WP_223131941.1	DUF2570 family protein	-
K7B08_RS13280	1727872..1728045	+	174	WP_227718007.1	lytic protein Rz1	-
K7B08_RS08725	1728083..1728499	-	417	WP_108511501.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
K7B08_RS08730	1728545..1728721	-	177	WP_169326243.1	type II toxin-antitoxin system HicA family toxin	Toxin
K7B08_RS08735	1728980..1729456	+	477	WP_075269225.1	DUF1441 family protein	-
K7B08_RS08740	1729459..1731567	+	2109	WP_223131943.1	phage terminase large subunit family protein	-
K7B08_RS08745	1731564..1731785	+	222	WP_014391481.1	hypothetical protein	-
K7B08_RS08750	1731782..1733320	+	1539	WP_223131944.1	phage portal protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1657073..1751757	94684

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-57)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-78)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6544.67 Da
• Isoelectric Point: 10.8207

>T214484 WP_169326243.1 NZ_CP082272:c1728721-1728545 [Pasteurella multocida]
MKQSEFLRWLKAQGVETKEGSNHIKLYLNGKQSALPRHPSKEIAKGTEIAVKKQLGLK

Nucleotide

• Length: 177 bp

>T214484 NZ_CP110110:c1006246-1005821 [Stutzerimonas balearica]
ATGATCCTGCTTGATACCAATGTGCTGTCTGAACTGATGCGAGCCAAGCCAGCGCCGCAGGTACTTGAGTGGGTCGACGC
CCAGCCGGCGAGCGAGTTAGCGATCAGTGCGATCACTGTTGCAGAGATTCTTTACGGCATTGCCAGAATGCCGGACGGCA
AGCGCAAACAAGGGCTGCTCGACATAGCCTCGGCCATGTTTGAGGAAGATTTCGCCGGCAATATTCTGCCGTTCGATGCA
GACGCCGCCGTTCACTATGCAGAGATTGCCGCGGCAACCGAAGCGAAGGGGCGGATAGTAGATATGGCAGACGCGCAGAT
CGCTGCGATTGGACGGCTACACGATGCAGTCATCGCGACTCGTAATGCCCGTCATTTCGAGCCACTGGGCGTGGCTTTGG
TCGACCCCTGGAGCGGGCGCGGGTAA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15553.84 Da
• Isoelectric Point: 4.5390

>AT214484 WP_108511501.1 NZ_CP082272:c1728499-1728083 [Pasteurella multocida]
MLYPAKFDKEDNGLYAVSFRDIPEALTCGDNFDDAVAMAKDALITSMDFYFEDFRKVPLPSEAKQDEVLIELPDSVFAKV
LLLNEMVEQNISNAELARRINVRPQEMQRITNISHSTKIDTISRALSALGKKLQLSVV

Nucleotide

• Length: 417 bp

>AT214484 NZ_CP110110:c1006488-1006243 [Stutzerimonas balearica]
ATGGCCAGCATTACGATCCGAAACCTTGACGACGACCTGAAGGCGAAGTTGCGCGTTTTAGCAGCTAGCCATGGGCGCTC
GATGGAAGAAGAAGCCCGAATCATCATTCGGCAAGCGCTGTCGCGTCAGGAAAAGCGTGGCGGGCTGGGTACTCGTATTC
ACTCCCGTTTTGCTTCGGTCGGCGGTGTGGATCTCGCCTTGCCTGAGCGAAAAGACAAGGCCCGAGCAGCGAGCTTCGAT
GAATGA