Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4854203..4854719 Replicon chromosome
Accession NZ_CP082212
Organism Klebsiella pneumoniae strain BJ20

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag K6039_RS24025 Protein ID WP_002886902.1
Coordinates 4854203..4854487 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag K6039_RS24030 Protein ID WP_002886901.1
Coordinates 4854477..4854719 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6039_RS24000 (K6039_23940) 4849687..4849995 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
K6039_RS24005 (K6039_23945) 4850080..4850253 + 174 WP_002886906.1 hypothetical protein -
K6039_RS24010 (K6039_23950) 4850256..4850999 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
K6039_RS24015 (K6039_23955) 4851356..4853494 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
K6039_RS24020 (K6039_23960) 4853735..4854199 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
K6039_RS24025 (K6039_23965) 4854203..4854487 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6039_RS24030 (K6039_23970) 4854477..4854719 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K6039_RS24035 (K6039_23975) 4854797..4856707 - 1911 WP_004152270.1 PRD domain-containing protein -
K6039_RS24040 (K6039_23980) 4856730..4857884 - 1155 WP_002886900.1 lactonase family protein -
K6039_RS24045 (K6039_23985) 4857950..4858690 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T214366 WP_002886902.1 NZ_CP082212:c4854487-4854203 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T214366 NZ_CP110054:c1492933-1492589 [Enterococcus faecalis]
ATGAAAAGTATCAAAGAGTTGGTGGAAGAATATGAAGTAGAGTTAGTTTTCGCTCCAATAAATAAGCGCGCATGTTACGA
GCCAGTCAAAAGAATAATTTTCGTAAATCAAAATTTATCTATCGAAGAACAAGAAGAGTCTATATTCCATGAGTTCAAAC
ATGTTGTCTCCCATTCGGATTATATTGAGTTATATAAAATTCCTTCTTTTAGAAATAAGATGGAAGCTGAGGCAGATTAT
CATATGTTTAAATGTCTTATTGAAAAACATGACGGGCAATTTAATTATTCTAATGTGATTACTCATTACAATTTAAAGAT
GGGACAGGAAACTTATTTAAATTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT214366 WP_002886901.1 NZ_CP082212:c4854719-4854477 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT214366 NZ_CP110054:c1493282-1492950 [Enterococcus faecalis]
ATGAACCTCTTGGAACGTATAAAAAAACTAGCAAAAGATAGAGATGTGTCTATTTATCAGCTTGAAGAAGAAATAAATAT
TGGACGAAATACTATTTATCAATGGAATAAGCGAACACCTTCTTCGGATAAACTTGAAGCTGTAGCCAATTATTTTAATG
TTTCTGTTGATTATTTATTAGGTCGTACTGAAAATCCAAACCAAGCTGGTGCTAAACCATCTGATGATTTAGATGAAGTA
TTAGACAATGTGATGAGTTTCGATGGTGAGCCTTTGGATGATCATGATCGGGAAGTTATTCGTGCTTATTTGAAAGGGAG
ATTCGGAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References