Detailed information of TA system TA214206

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 869750..870410
• Replicon: chromosome
• Accession: NZ_CP082141
• Organism: Erwinia persicina strain Cp2

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: K6L24_RS03990
• Protein ID: WP_062744287.1
• Coordinates: 869997..870410 (+)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A354DN60
• Locus tag: K6L24_RS03985
• Protein ID: WP_062744288.1
• Coordinates: 869750..870016 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K6L24_RS03965 (K6L24_03965)	866202..866945	+	744	WP_118663257.1	SDR family oxidoreductase	-
K6L24_RS03970 (K6L24_03970)	867050..867658	-	609	WP_062744290.1	HD domain-containing protein	-
K6L24_RS03975 (K6L24_03975)	867868..868521	+	654	WP_118665636.1	hemolysin III family protein	-
K6L24_RS03980 (K6L24_03980)	868537..869523	-	987	WP_062744289.1	tRNA-modifying protein YgfZ	-
K6L24_RS03985 (K6L24_03985)	869750..870016	+	267	WP_062744288.1	FAD assembly factor SdhE	Antitoxin
K6L24_RS03990 (K6L24_03990)	869997..870410	+	414	WP_062744287.1	protein YgfX	Toxin
K6L24_RS03995 (K6L24_03995)	870403..871098	+	696	WP_062744286.1	two-component system response regulator CreB	-
K6L24_RS04000 (K6L24_04000)	871098..872522	+	1425	WP_191927640.1	two-component system sensor histidine kinase CreC	-
K6L24_RS04005 (K6L24_04005)	872605..873966	+	1362	WP_137269030.1	cell envelope integrity protein CreD	-
K6L24_RS04010 (K6L24_04010)	874064..874582	-	519	WP_062744283.1	flavodoxin FldB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-130)

Antitoxin

• Flavinator of succinate dehydrogenase (8-79)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 16162.98 Da
• Isoelectric Point: 11.8432

>T214206 WP_062744287.1 NZ_CP082141:869997-870410 [Erwinia persicina]
VVRCHCNLRLSRHAQSLSLLLHGGVMLLLLLAPWPPEASLVKVALLLLTGGECLRSCRRTRRWQGLFVLLSGRRVQWHQA
QWQMVSPPWMTRHAVRLSLRDNQGRHERLWLFADGMDNSEWRLLRQQLLSKKEWRDE

Nucleotide

• Length: 414 bp

>T214206 NZ_CP110015:c2178726-2178475 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10580.97 Da
• Isoelectric Point: 4.5392

>AT214206 WP_062744288.1 NZ_CP082141:869750-870016 [Erwinia persicina]
MDISNKSRIHWACRRGMRELDISIMPFFEYEYDSLNDQDKQLFVRLLENDDPDLFNWLMNHGEPADDELKRMVALIQDRN
RERGPVPL

Nucleotide

• Length: 267 bp

>AT214206 NZ_CP110015:c2178478-2178224 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Structures

Antitoxin

• AlphaFold DB: A0A354DN60