Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1941574..1942409 Replicon chromosome
Accession NZ_CP082129
Organism Escherichia coli strain NDM_11.16372

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1U9SHU4
Locus tag K5P77_RS09265 Protein ID WP_000854752.1
Coordinates 1941574..1941951 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID E3PJ72
Locus tag K5P77_RS09270 Protein ID WP_001278232.1
Coordinates 1942041..1942409 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5P77_RS09230 (1937094) 1937094..1937567 + 474 WP_001105384.1 DNA gyrase inhibitor SbmC -
K5P77_RS09235 (1937765) 1937765..1938823 + 1059 WP_001200892.1 FUSC family protein -
K5P77_RS09240 (1938995) 1938995..1939324 + 330 WP_000450409.1 DUF496 family protein -
K5P77_RS24445 (1939425) 1939425..1939790 - 366 WP_223350516.1 EutP/PduV family microcompartment system protein -
K5P77_RS09250 (1940061) 1940061..1940432 - 372 WP_001295631.1 IS110 family transposase -
K5P77_RS09255 (1941248) 1941248..1941328 - 81 Protein_1825 hypothetical protein -
K5P77_RS09260 (1941428) 1941428..1941577 - 150 Protein_1826 DUF5983 family protein -
K5P77_RS09265 (1941574) 1941574..1941951 - 378 WP_000854752.1 TA system toxin CbtA family protein Toxin
K5P77_RS09270 (1942041) 1942041..1942409 - 369 WP_001278232.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
K5P77_RS09275 (1942572) 1942572..1942793 - 222 WP_000692345.1 DUF987 domain-containing protein -
K5P77_RS09280 (1942856) 1942856..1943332 - 477 WP_001186774.1 RadC family protein -
K5P77_RS09285 (1943546) 1943546..1945087 + 1542 WP_002431311.1 IS21-like element ISEc12 family transposase -
K5P77_RS09290 (1945102) 1945102..1945848 + 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -
K5P77_RS09295 (1945934) 1945934..1946407 - 474 WP_000855059.1 antirestriction protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14076.08 Da        Isoelectric Point: 8.2905

>T214182 WP_000854752.1 NZ_CP082129:c1941951-1941574 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T214182 NZ_CP110014:2868574-2868903 [Escherichia coli]
ATGAACACTCTACCTGCTACAATTTCGCAGGCGGCGAAGCCCTGCCTGTCGCCAGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAACACTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATCG
ATGCTGGTATCACTCTGGCCGATGCAGTCAATTTTCTGGTGGAAAAGTACGAACTGGTACGTATCGATCACAGAGGATTT
TCGTGGCAACAACAGTCTCCATATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13491.37 Da        Isoelectric Point: 6.6290

>AT214182 WP_001278232.1 NZ_CP082129:c1942409-1942041 [Escherichia coli]
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT214182 NZ_CP110014:2868236-2868553 [Escherichia coli]
ATGAGCAACACCACATGGGGCCTGCAGCGAGATATCACGCCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCAGCT
GCACTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTTAGTGACGCCGAATGTCCTAAGCTGGATGTGGTATTTCCAC
ATTTTATCAGCCAGATAGAGTCGATGCTGACCACTGGTGAACTGAATCCCCGCCATGCCCAATGCGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTGCGGCTACGTATACATCGCTGTTTACCCCACTCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1U9SHU4

Antitoxin

Source ID Structure
AlphaFold DB E3PJ72

References