Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 49350..50148 Replicon chromosome
Accession NZ_CP082120
Organism Escherichia coli strain PC-NDM34

Toxin (Protein)


Gene name yeeV Uniprot ID U9XMP3
Locus tag K5P75_RS00250 Protein ID WP_000854735.1
Coordinates 49350..49727 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A067H947
Locus tag K5P75_RS00255 Protein ID WP_001285415.1
Coordinates 49774..50148 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5P75_RS00225 (44698) 44698..45621 - 924 WP_000535971.1 carboxylate/amino acid/amine transporter -
K5P75_RS00230 (45732) 45732..46916 - 1185 WP_001172876.1 sugar efflux transporter -
K5P75_RS25315 (47313) 47313..47474 - 162 Protein_46 virulence RhuM family protein -
K5P75_RS00235 (47711) 47711..48553 - 843 WP_000036707.1 DUF4942 domain-containing protein -
K5P75_RS00240 (48650) 48650..48847 - 198 WP_000839266.1 DUF957 domain-containing protein -
K5P75_RS00245 (48865) 48865..49353 - 489 WP_000761680.1 DUF5983 family protein -
K5P75_RS00250 (49350) 49350..49727 - 378 WP_000854735.1 TA system toxin CbtA family protein Toxin
K5P75_RS00255 (49774) 49774..50148 - 375 WP_001285415.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
K5P75_RS00260 (50228) 50228..50449 - 222 WP_000692309.1 DUF987 domain-containing protein -
K5P75_RS00265 (50512) 50512..50988 - 477 WP_001342696.1 RadC family protein -
K5P75_RS00270 (51003) 51003..51482 - 480 WP_001757700.1 antirestriction protein -
K5P75_RS00275 (51564) 51564..52382 - 819 WP_113344608.1 DUF932 domain-containing protein -
K5P75_RS00280 (52472) 52472..52705 - 234 WP_001278287.1 DUF905 family protein -
K5P75_RS00285 (52711) 52711..53388 - 678 WP_001097301.1 hypothetical protein -
K5P75_RS00290 (53536) 53536..54216 - 681 WP_001282919.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14061.07 Da        Isoelectric Point: 8.2904

>T214112 WP_000854735.1 NZ_CP082120:c49727-49350 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T214112 NZ_CP109965:c2792346-2792035 [Catenovulum sp. TS8]
ATGCACGTAATATCAAGAAAACCATTTAGTGATGCTGCGAAAAAATATCCGAATGATGCTGCAGCAATTGATGCATTATA
TAAATCATTAAAAAATAATAATTTTTCAAATCCACTGGAGATGAAAAATTTTTATCCAAGCTTAGACAACTTTAAATATA
AAGATAAGTGGTATGTTCTTGATATCGGTGGGAATAATTTACGATTAATGACTTTTATCGAGTTTCGAGATAATAGAATG
TTTGTTAAGTATATTGTTCCTCATGCAGAATATGACAAGCTATGCACCAAATACGCAAAGGAGTCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13663.32 Da        Isoelectric Point: 5.8640

>AT214112 WP_001285415.1 NZ_CP082120:c50148-49774 [Escherichia coli]
VSDTHPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT214112 NZ_CP109965:c2792038-2791610 [Catenovulum sp. TS8]
ATGAAAAATTTTAATCAAATTAAATCAACAGCATTACAATTATTTTCAATGGCTAGTTTTGTTAGTCATATTTCAACAGA
AGAAGAATATACTGAAGCTTTGGCGTTAATGGAAGATCTTATTAAAGAGTACGATATTTACAAACCATTAATTGAGGTTT
TAGAGGTATCTATCGAGCGTTGGGAAGACAGTGCAGATGAATTTGCAGAGTTTAATGCTCGTATTGAGAATTTAGATGAT
GGGGTGGCAACACTGCGTGTATTAATTGATCAGTATCAACTTAAAGCTGATGACCTAAAAGATGTCATTGGTGGTAAAAG
TTTGGTTTCAATGATCCTTAACGGTTCTCGTAAGCTGACAAAAGAGCATATTCAAGCCATTTCATCTAAATATAATATCA
GCCCTGCATTGTTTTTTGGCTGCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XMP3

Antitoxin

Source ID Structure
AlphaFold DB A0A067H947

References