213972

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 212..686 Replicon plasmid pKP18-2073-4
Accession NZ_CP082023
Organism Klebsiella pneumoniae strain KP18-2073

Toxin (Protein)


Gene name pasB Uniprot ID A0A8J3DT22
Locus tag K6166_RS00010 Protein ID WP_004197762.1
Coordinates 212..478 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID S1EJF5
Locus tag K6166_RS00015 Protein ID WP_000879771.1
Coordinates 462..686 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6166_RS00010 212..478 - 267 WP_004197762.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6166_RS00015 462..686 - 225 WP_000879771.1 DUF6290 family protein Antitoxin
K6166_RS30295 849..977 + 129 WP_000523570.1 hypothetical protein -
K6166_RS00020 1353..1565 - 213 WP_021527181.1 MbeD family mobilization/exclusion protein -
K6166_RS00025 1572..2081 - 510 WP_032433972.1 MbeB family mobilization protein -
K6166_RS30300 2116..2550 - 435 Protein_6 relaxase/mobilization nuclease domain-containing protein -
K6166_RS00035 2759..3103 - 345 WP_062955149.1 MobC family plasmid mobilization relaxosome protein -
K6166_RS00040 3093..3269 - 177 WP_004197757.1 hypothetical protein -
K6166_RS00045 4425..4751 + 327 WP_050516389.1 hypothetical protein -
K6166_RS00050 4777..5322 + 546 WP_023317533.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..5596 5596


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Relaxosome protein TraY

(4-45)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10342.96 Da        Isoelectric Point: 9.8727

>T213972 WP_004197762.1 NZ_CP082023:c478-212 [Klebsiella pneumoniae]
MVWTINYSDRALKSLRKMDKQNARRIVDFMSLRIAVAADPRQSGKPLKGELGEFWRYRVGDYRVLCEIRDDELVILAATI
GHRREVYD

Download         Length: 267 bp

>T213972 NZ_CP109929:2842404-2842511 [Escherichia coli O6:K2:H1]
ATGACGCTCGCGCAGTTTGCCGTGATTTTCTGGCACGACCTGGCAGCACCGATCCTTGCGGGAATTATTACCGCAGCGAT
TGTTGGCTGGTGGCGTAGCCGGAAGTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8369.28 Da        Isoelectric Point: 4.6533

>AT213972 WP_000879771.1 NZ_CP082023:c686-462 [Klebsiella pneumoniae]
MLAIRLSDEIESRLDSLAKQTGRTKTFYAREAILAHLEDLEDYYLSAETAARVRRGDEAVHSSEDVRKSLGLDD

Download         Length: 225 bp

>AT213972 NZ_CP109929:c2842348-2842287 [Escherichia coli O6:K2:H1]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTGACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S1EJF5

References