Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1035757..1036341 Replicon chromosome
Accession NZ_CP081939
Organism Avibacterium paragallinarum strain p4chr1

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag K5O18_RS05165 Protein ID WP_110478986.1
Coordinates 1036063..1036341 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K5O18_RS05160 Protein ID WP_110478985.1
Coordinates 1035757..1036053 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5O18_RS05145 (K5O18_05145) 1031670..1032149 + 480 WP_110478982.1 leucine-responsive transcriptional regulator Lrp -
K5O18_RS05150 (K5O18_05150) 1032151..1035003 + 2853 WP_110478983.1 DNA translocase FtsK 4TM domain-containing protein -
K5O18_RS05155 (K5O18_05155) 1035085..1035705 + 621 WP_194742997.1 outer membrane lipoprotein chaperone LolA -
K5O18_RS05160 (K5O18_05160) 1035757..1036053 - 297 WP_110478985.1 HigA family addiction module antitoxin Antitoxin
K5O18_RS05165 (K5O18_05165) 1036063..1036341 - 279 WP_110478986.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K5O18_RS05170 (K5O18_05170) 1036494..1037843 + 1350 WP_110478987.1 replication-associated recombination protein A -
K5O18_RS05175 (K5O18_05175) 1037917..1039206 + 1290 WP_110478988.1 serine--tRNA ligase -
K5O18_RS05180 (K5O18_05180) 1039410..1040492 + 1083 WP_110478989.1 peptide chain release factor 1 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-67)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10852.50 Da        Isoelectric Point: 8.5384

>T213804 WP_110478986.1 NZ_CP081939:c1036341-1036063 [Avibacterium paragallinarum]
MITHFTCKDTQAFFEGQRIRRFIPFEKVAMRKLQQLNAATELDFLRIPPGNHLEMLTGDRKGQYSIRINDQWRICFTWLN
GHAADVAIVDYH

Download         Length: 279 bp

>T213804 NZ_CP109872:248819-249169 [Bacillus cereus]
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGCGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCAACGGTGATTGTAGCGGCTATTACTGCACAGATTCAAAAAG
CGAAATTACCCACTCATGTGGAAATTGATGCGAAAAAGTACGGTTTTGAGAGAGATTCTGTTATTTTACTTGAGCAGATT
CGAACAATCGATAAGCAGCGCTTAACGGACAAAATCACTCACTTAGATGAAGTGATGATGATTCGTGTAGATGAAGCGCT
ACAAATTAGTTTAGGACTAATAGATTTTTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11127.72 Da        Isoelectric Point: 7.3167

>AT213804 WP_110478985.1 NZ_CP081939:c1036053-1035757 [Avibacterium paragallinarum]
MTRQIPLSHPGEILLEEWLKPLGISQYALAKAISVPPRRINEIVKGKRAITPDTALRLATYFGTDPQSWLNLQSHYDTEQ
TRTAINEDLTHISPFQFA

Download         Length: 297 bp

>AT213804 NZ_CP109872:248527-248814 [Bacillus cereus]
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAATGGTAACGGAATTGGACGGAATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAACTGTTATTGCGTCAACATAAGACGAAGAAACGCT
ACCAACATGAATCAATGCGACGTGGGTACATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCA
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References