Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 357838..358484 Replicon chromosome
Accession NZ_CP081891
Organism Klebsiella pneumoniae strain CT-04

Toxin (Protein)


Gene name higB Uniprot ID A0A483PC41
Locus tag KZ663_RS01655 Protein ID WP_004216295.1
Coordinates 357838..358185 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag KZ663_RS01660 Protein ID WP_002920557.1
Coordinates 358185..358484 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ663_RS01645 (KZ663_01640) 353764..355197 + 1434 WP_004889438.1 glycogen synthase GlgA -
KZ663_RS01650 (KZ663_01645) 355215..357662 + 2448 WP_002920561.1 glycogen phosphorylase -
KZ663_RS01655 (KZ663_01650) 357838..358185 + 348 WP_004216295.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KZ663_RS01660 (KZ663_01655) 358185..358484 + 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
KZ663_RS01665 (KZ663_01660) 358547..360055 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
KZ663_RS01670 (KZ663_01665) 360260..360589 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
KZ663_RS01675 (KZ663_01670) 360640..361470 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
KZ663_RS01680 (KZ663_01675) 361520..362278 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13606.61 Da        Isoelectric Point: 5.6749

>T213677 WP_004216295.1 NZ_CP081891:357838-358185 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCADNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T213677 NZ_CP109775:c1752651-1752544 [Shigella sonnei]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT213677 WP_002920557.1 NZ_CP081891:358185-358484 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT213677 NZ_CP109775:1752704-1752765 [Shigella sonnei]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483PC41

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References