Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1980962..1981806 Replicon chromosome
Accession NZ_CP081881
Organism Escherichia coli strain WW2

Toxin (Protein)


Gene name yeeV Uniprot ID B1LJY4
Locus tag K5O11_RS09315 Protein ID WP_000854686.1
Coordinates 1981423..1981806 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag K5O11_RS09310 Protein ID WP_219365756.1
Coordinates 1980962..1981342 (+) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5O11_RS09275 (1977210) 1977210..1977665 + 456 WP_000581506.1 IrmA family protein -
K5O11_RS09280 (1977766) 1977766..1977974 + 209 Protein_1825 DUF905 domain-containing protein -
K5O11_RS09285 (1978075) 1978075..1978896 + 822 WP_001761104.1 DUF932 domain-containing protein -
K5O11_RS09290 (1978988) 1978988..1979473 + 486 WP_000214307.1 antirestriction protein -
K5O11_RS09295 (1979489) 1979489..1979965 + 477 WP_001186726.1 RadC family protein -
K5O11_RS09300 (1980028) 1980028..1980249 + 222 WP_000692298.1 DUF987 domain-containing protein -
K5O11_RS09305 (1980268) 1980268..1980951 + 684 WP_000086768.1 hypothetical protein -
K5O11_RS09310 (1980962) 1980962..1981342 + 381 WP_219365756.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
K5O11_RS09315 (1981423) 1981423..1981806 + 384 WP_000854686.1 TA system toxin CbtA family protein Toxin
K5O11_RS09320 (1981803) 1981803..1982291 + 489 WP_032180032.1 DUF5983 family protein -
K5O11_RS09325 (1982308) 1982308..1982505 + 198 WP_000839253.1 DUF957 domain-containing protein -
K5O11_RS09330 (1982590) 1982590..1983431 + 842 Protein_1835 DUF4942 domain-containing protein -
K5O11_RS09340 (1983902) 1983902..1984840 + 939 WP_061092643.1 glyoxylate/hydroxypyruvate reductase GhrA -
K5O11_RS09345 (1984895) 1984895..1985632 + 738 WP_061092644.1 zinc-binding phosphatase -
K5O11_RS09350 (1985656) 1985656..1986210 + 555 WP_001001920.1 molecular chaperone YcdY -
K5O11_RS09355 (1986312) 1986312..1986803 + 492 WP_001308552.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island blaCMY-2 csgG / csgF / csgE / csgD / csgB / csgA / csgC 1934778..1992370 57592


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-113)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14272.28 Da        Isoelectric Point: 6.8614

>T213609 WP_000854686.1 NZ_CP081881:1981423-1981806 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Download         Length: 384 bp

>T213609 NZ_CP109730:c56458-56171 [Enterobacter roggenkampii]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13954.73 Da        Isoelectric Point: 5.0823

>AT213609 WP_219365756.1 NZ_CP081881:1980962-1981342 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPLE

Download         Length: 381 bp

>AT213609 NZ_CP109730:c56697-56458 [Enterobacter roggenkampii]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References