Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1195538..1196158 Replicon chromosome
Accession NZ_CP081858
Organism Salmonella enterica subsp. enterica serovar Schwarzengrund strain S16

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag K6B66_RS05685 Protein ID WP_001280991.1
Coordinates 1195538..1195756 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag K6B66_RS05690 Protein ID WP_000344807.1
Coordinates 1195784..1196158 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6B66_RS05645 (1190761) 1190761..1191330 + 570 WP_000779802.1 YbaY family lipoprotein -
K6B66_RS05650 (1191363) 1191363..1191752 - 390 WP_000961285.1 MGMT family protein -
K6B66_RS05660 (1191983) 1191983..1193533 - 1551 WP_000213134.1 EAL domain-containing protein -
K6B66_RS05665 (1193758) 1193758..1194018 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
K6B66_RS05670 (1194024) 1194024..1194164 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
K6B66_RS05675 (1194220) 1194220..1194690 - 471 WP_000136183.1 YlaC family protein -
K6B66_RS05680 (1194808) 1194808..1195359 - 552 WP_001278791.1 maltose O-acetyltransferase -
K6B66_RS05685 (1195538) 1195538..1195756 - 219 WP_001280991.1 HHA domain-containing protein Toxin
K6B66_RS05690 (1195784) 1195784..1196158 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
K6B66_RS05695 (1196654) 1196654..1199803 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
K6B66_RS05700 (1199826) 1199826..1201019 - 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T213552 WP_001280991.1 NZ_CP081858:c1195756-1195538 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T213552 NZ_CP109619:2431331-2431591 [Treponema denticola]
ATGTGGAATGTAGTTTATTCAAAACAAGCTGCAAAAGACAGTAAAAAAATTGAACAATCCAATTTAAAAGAAAGCGTTAA
GAGATTGATAGAAGTTTTGAAAAACGATCCATTTCAAAATCCGCCGCCTTATGAAAAATTAATAGGTGATTTAACAGGAA
AGTTTTCAAGAAGAATAAATCTTCAGCATCGGCTTGTGTATGAAGTTTTTGAAAAGGAAATGATTGTTCGTGTTCTTCGA
ATGTGGACTCATTATGAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT213552 WP_000344807.1 NZ_CP081858:c1196158-1195784 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT213552 NZ_CP109619:2431089-2431331 [Treponema denticola]
ATGACGATAATGACAGCAACAGCAGCTAGAACAAATTTATATAATCTTATTGACCGGACAAAAGAATTTCACGAACCGAT
TATTATTTCAGGAAAAAGAAATAATGCAGTATTGATATCGGAAGATGATTGGAATTCAATTCAGGAAACATTATATTTAT
GTTCTATTCCGGGAATGAGAGAATCTATTCTTGAAGCGAGTGAAGAATCTTTGGAAGAAAGCGTAAAGGAACTGGATTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References