Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 3403606..3404220 Replicon chromosome
Accession NZ_CP081826
Organism Stenotrophomonas sp. DR822

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag K5K93_RS15635 Protein ID WP_222388360.1
Coordinates 3403606..3403920 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K5K93_RS15640 Protein ID WP_093818027.1
Coordinates 3403924..3404220 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5K93_RS15620 (K5K93_15620) 3400207..3401319 + 1113 WP_093818030.1 rod shape-determining protein RodA -
K5K93_RS15625 (K5K93_15625) 3401609..3402019 - 411 WP_222388359.1 hypothetical protein -
K5K93_RS15630 (K5K93_15630) 3402442..3403518 + 1077 WP_222391101.1 rod shape-determining protein RodA -
K5K93_RS15635 (K5K93_15635) 3403606..3403920 + 315 WP_222388360.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K5K93_RS15640 (K5K93_15640) 3403924..3404220 + 297 WP_093818027.1 NadS family protein Antitoxin
K5K93_RS15645 (K5K93_15645) 3404816..3405961 + 1146 WP_033832243.1 lytic murein transglycosylase B -
K5K93_RS15650 (K5K93_15650) 3405958..3407202 + 1245 WP_222388361.1 septal ring lytic transglycosylase RlpA family protein -
K5K93_RS15655 (K5K93_15655) 3407305..3408522 + 1218 WP_032975369.1 D-alanyl-D-alanine carboxypeptidase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(42-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-97)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11709.49 Da        Isoelectric Point: 10.0582

>T213519 WP_222388360.1 NZ_CP081826:3403606-3403920 [Stenotrophomonas sp. DR822]
MIFIETPTFTRLIKELMTDTQYSGFQHTLAQAPESGDLIEGTGGLRKIRVALPGRGKRSGARVIYYHFASASQIVLLLAY
PKNEQDNLTAEQKKALRSIIENWK

Download         Length: 315 bp

>T213519 NZ_CP109608:87781-88263 [Klebsiella pneumoniae]
GTGGGACGTTTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTGGCTGAGTTCGTCAGCGGTGAGGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCCCTCGGAGCTGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGCAGCGTCAACCATACAGAAGCGACAGGCAATCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGCGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAACCATCACAAACTCAGCAGCGAACATTGTTTCTTAGACTCCCT
TAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10994.64 Da        Isoelectric Point: 10.1983

>AT213519 WP_093818027.1 NZ_CP081826:3403924-3404220 [Stenotrophomonas sp. DR822]
MDKNLFAELMGSVSEANEILKGERSPSRELYISPVEVREIRKATGLSQQKFATIIHVEVGTLRNWEQGRRDPTGPARALL
HVIKKNPKETLRALADVS

Download         Length: 297 bp

>AT213519 NZ_CP109608:87506-87793 [Klebsiella pneumoniae]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAATGGCCTGTCAGGCTGCCGAGAATGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGCGGAGTTCATCGACATGCTTGATGCACCTGTCGTAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References