Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 53910..54429 | Replicon | plasmid unnamed 1 |
| Accession | NZ_CP081783 | ||
| Organism | Escherichia coli strain 0H26 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | A0A837F4A9 |
| Locus tag | J6O44_RS24740 | Protein ID | WP_000277490.1 |
| Coordinates | 54145..54429 (+) | Length | 95 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | A0A6P1V8C3 |
| Locus tag | J6O44_RS24735 | Protein ID | WP_000124732.1 |
| Coordinates | 53910..54152 (+) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J6O44_RS24715 (J6O44_24600) | 49635..49745 | + | 111 | Protein_53 | recombinase family protein | - |
| J6O44_RS24720 (J6O44_24605) | 49807..50511 | + | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| J6O44_RS24725 (J6O44_24610) | 50573..52507 | + | 1935 | Protein_55 | Tn3 family transposase | - |
| J6O44_RS24730 (J6O44_24615) | 52525..53337 | + | 813 | WP_257606735.1 | plasmid replication initiator RepA | - |
| J6O44_RS24735 (J6O44_24620) | 53910..54152 | + | 243 | WP_000124732.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| J6O44_RS24740 (J6O44_24625) | 54145..54429 | + | 285 | WP_000277490.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| J6O44_RS24745 (J6O44_24630) | 54567..54659 | - | 93 | Protein_59 | plasmid partition protein ParG | - |
| J6O44_RS24750 | 54979..55197 | - | 219 | Protein_60 | IS110 family transposase | - |
| J6O44_RS24755 (J6O44_24635) | 55198..55497 | - | 300 | Protein_61 | glycogen/starch synthase | - |
| J6O44_RS24760 (J6O44_24640) | 55497..56018 | - | 522 | Protein_62 | glucose-1-phosphate adenylyltransferase | - |
| J6O44_RS24765 (J6O44_24645) | 56081..56785 | + | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| J6O44_RS24770 (J6O44_24650) | 56884..57024 | + | 141 | WP_045286941.1 | helix-turn-helix domain-containing protein | - |
| J6O44_RS24775 (J6O44_24655) | 57122..57538 | - | 417 | WP_088765932.1 | type II toxin-antitoxin system VapC family toxin | - |
| J6O44_RS24780 (J6O44_24660) | 57535..57765 | - | 231 | WP_001261282.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| J6O44_RS24785 (J6O44_24665) | 57722..58183 | + | 462 | WP_223584524.1 | hypothetical protein | - |
| J6O44_RS24790 (J6O44_24670) | 58327..58677 | + | 351 | WP_000493399.1 | hypothetical protein | - |
| J6O44_RS27530 | 58721..58843 | + | 123 | WP_257606738.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | - | 1..303840 | 303840 | |
| - | inside | IScluster/Tn | - | - | 49807..84396 | 34589 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 95 a.a. Molecular weight: 11005.52 Da Isoelectric Point: 6.2103
>T213414 WP_000277490.1 NZ_CP081783:54145-54429 [Escherichia coli]
VYKLTERAADDFAGIYDYTLLKFGEAQADHYTDALEAFFETLAGMPDMGRDYHTVPGVMRIEFQRHAIFYTVRDTDILIA
RILHQQMNHKRHLL
VYKLTERAADDFAGIYDYTLLKFGEAQADHYTDALEAFFETLAGMPDMGRDYHTVPGVMRIEFQRHAIFYTVRDTDILIA
RILHQQMNHKRHLL
Download Length: 285 bp
>T213414 NZ_CP107613:c19402-19115 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGATATACTAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGATATACTAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG
Antitoxin
Download Length: 81 a.a. Molecular weight: 8875.01 Da Isoelectric Point: 7.0130
>AT213414 WP_000124732.1 NZ_CP081783:53910-54152 [Escherichia coli]
MARTTSVTIGEQLDSFISRLIDSGRYGSASEVMRSALRLLEQQETNDEVIRQAVIAGLESGESSLSLRDIAAQRKLRHRV
MARTTSVTIGEQLDSFISRLIDSGRYGSASEVMRSALRLLEQQETNDEVIRQAVIAGLESGESSLSLRDIAAQRKLRHRV
Download Length: 243 bp
>AT213414 NZ_CP107613:c19128-18814 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A837F4A9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6P1V8C3 |