Detailed information of TA system TA213406

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/UPF0150(antitoxin)
• Location: 2704832..2705470
• Replicon: chromosome
• Accession: NZ_CP081782
• Organism: Escherichia coli strain 0H26

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S1F9G9
• Locus tag: J6O44_RS13310
• Protein ID: WP_000813794.1
• Coordinates: 2705294..2705470 (-)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: J6O44_RS13305
• Protein ID: WP_001270286.1
• Coordinates: 2704832..2705248 (-)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J6O44_RS13285 (2699984)	2699984..2700925	-	942	WP_001251313.1	ABC transporter permease	-
J6O44_RS13290 (2700926)	2700926..2701939	-	1014	WP_000220434.1	ABC transporter ATP-binding protein	-
J6O44_RS13295 (2701957)	2701957..2703102	-	1146	WP_000047430.1	ABC transporter substrate-binding protein	-
J6O44_RS13300 (2703347)	2703347..2704753	-	1407	WP_000760630.1	PLP-dependent aminotransferase family protein	-
J6O44_RS13305 (2704832)	2704832..2705248	-	417	WP_001270286.1	type II toxin-antitoxin system antitoxin HicB	Antitoxin
J6O44_RS13310 (2705294)	2705294..2705470	-	177	WP_000813794.1	type II toxin-antitoxin system mRNA interferase toxin HicA	Toxin
J6O44_RS13315 (2705692)	2705692..2705922	+	231	WP_000494244.1	YncJ family protein	-
J6O44_RS13320 (2706014)	2706014..2707975	-	1962	WP_001488038.1	23S rRNA 5-hydroxycytidine C2501 synthase	-
J6O44_RS13325 (2708048)	2708048..2708584	-	537	WP_000429169.1	DNA-binding transcriptional regulator SutR	-
J6O44_RS13330 (2708676)	2708676..2709851	+	1176	WP_001236305.1	BenE family transporter YdcO	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-57)

Antitoxin

• Cro/C1-type helix-turn-helix domain (91-134)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6749.83 Da
• Isoelectric Point: 11.2298

>T213406 WP_000813794.1 NZ_CP081782:c2705470-2705294 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Nucleotide

• Length: 177 bp

>T213406 NZ_CP107608:c3489891-3489502 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTCAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCGCGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCCATTAA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15246.63 Da
• Isoelectric Point: 4.7386

>AT213406 WP_001270286.1 NZ_CP081782:c2705248-2704832 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Nucleotide

• Length: 417 bp

>AT213406 NZ_CP107608:c3490155-3489898 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACTTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ATCCTGATTTACTCGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Structures

Toxin

• PDB: 6HPB