Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 44506..45031 Replicon plasmid unnamed2
Accession NZ_CP081764
Organism Escherichia coli strain CX21

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag J6O46_RS25440 Protein ID WP_016240353.1
Coordinates 44506..44811 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A8H9ZZC6
Locus tag J6O46_RS25445 Protein ID WP_016240352.1
Coordinates 44813..45031 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6O46_RS25420 (J6O46_25315) 40901..41452 + 552 WP_223610888.1 hypothetical protein -
J6O46_RS25425 (J6O46_25320) 41486..42183 + 698 WP_223610889.1 IS1 family transposase -
J6O46_RS25430 (J6O46_25325) 42329..43123 - 795 WP_016240356.1 site-specific integrase -
J6O46_RS25435 (J6O46_25330) 43321..44336 - 1016 Protein_55 hypothetical protein -
J6O46_RS25440 (J6O46_25335) 44506..44811 - 306 WP_016240353.1 type II toxin-antitoxin system toxin CcdB Toxin
J6O46_RS25445 (J6O46_25340) 44813..45031 - 219 WP_016240352.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
J6O46_RS25450 (J6O46_25345) 45631..45861 + 231 WP_001261283.1 type II toxin-antitoxin system VapB family antitoxin -
J6O46_RS25455 (J6O46_25350) 45858..46274 + 417 WP_032192044.1 type II toxin-antitoxin system VapC family toxin -
J6O46_RS25460 (J6O46_25355) 46310..46561 + 252 WP_105966327.1 hypothetical protein -
J6O46_RS25465 (J6O46_25360) 46642..47742 - 1101 WP_032192045.1 NADH:flavin oxidoreductase/NADH oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..94675 94675


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11518.20 Da        Isoelectric Point: 5.6752

>T213328 WP_016240353.1 NZ_CP081764:c44811-44506 [Escherichia coli]
MQFKVYAYKRESCYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRDLYPVVHIGDDSYRLMTTDMASVTASVTGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

>T213328 NZ_CP107548:c1206056-1205754 [Pusillimonas sp. M17]
ATGGGAACCATCAAACTACGCAAGTGGGATATCATCGAATACCTCAAGACCGAGGAAGATATGGTGATGTACCTGCAAGC
CTGCATGGATGAAGCGGGTGACGATGCCGCCTTCATCGCGGCGGCTCTCGGCGACATTGCCCGAGCCAAAGGCATGACGC
AACTTGCAAAGGATACGGGTCTGGGGCGCGAAAGCCTTTACAAGGCACTGTCCGGCGAGGGCAACCCGAGCTTCGGCACC
ATCCTGAAGGTCATGCACGCGCTCGGTATCAAGCTGCACCCTGAAGCCGCTACTCACGCTTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8321.25 Da        Isoelectric Point: 4.5358

>AT213328 WP_016240352.1 NZ_CP081764:c45031-44813 [Escherichia coli]
MKQRITVTIDSDSYQLLKSADVNISGLVNTAMQNEARRLRAERWQAENQEGMAEVARFIEMNGSFAEENRDW

Download         Length: 219 bp

>AT213328 NZ_CP107548:c1206359-1206069 [Pusillimonas sp. M17]
ATGAAAACGATCCACACCACCGATACGTTCGATGATTGGTTCGTCGGGTTACGCGATAGGATGGCTCAGAAGCGAATCCA
AGCAAGGATACGCCGCGCTGAGTTTGGCAACTTCGGCGACTGTGAGCCTGTGGGCGAAGGCGTCTCGGAGATGCGAATTC
ACTACGGGCCGGGCTACCGCGTGTATTTTGTACAGCGTGGCCTGGAAATTGTGATCTTGCTCGCCGGTGGCGATAAATCC
ACGCAGAGTCAGGACATCAAGACTGCACTGAATCTGGTGCAACAACTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References