Detailed information of TA system TA021293

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1731924..1732624
• Replicon: chromosome
• Accession: NC_007511
• Organism: Burkholderia lata

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: Q396G0
• Locus tag: BCEP18194_RS30470
• Protein ID: WP_011355140.1
• Coordinates: 1732328..1732624 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q396G1
• Locus tag: BCEP18194_RS30465
• Protein ID: WP_011355139.1
• Coordinates: 1731924..1732325 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BCEP18194_RS30445	1727566..1728918	-	1353	WP_011355135.1	LLM class flavin-dependent oxidoreductase	-
BCEP18194_RS30450	1728926..1729975	-	1050	WP_011355136.1	LLM class flavin-dependent oxidoreductase	-
BCEP18194_RS30455	1730039..1730986	-	948	WP_011355137.1	ABC transporter substrate-binding protein	-
BCEP18194_RS30460	1731043..1731603	-	561	WP_041493299.1	GNAT family N-acetyltransferase	-
BCEP18194_RS30465	1731924..1732325	-	402	WP_011355139.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
BCEP18194_RS30470	1732328..1732624	-	297	WP_011355140.1	type II toxin-antitoxin system MqsR family toxin	Toxin
BCEP18194_RS30475	1732728..1733768	-	1041	WP_011355141.1	succinylglutamate desuccinylase/aspartoacylase family protein	-
BCEP18194_RS30480	1734023..1734298	-	276	WP_011355142.1	hypothetical protein	-
BCEP18194_RS30485	1734556..1736106	-	1551	WP_011355143.1	sensor domain-containing diguanylate cyclase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (2-97)

Antitoxin

• Cro/C1-type helix-turn-helix domain (72-109)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11195.06 Da
• Isoelectric Point: 9.5731

>T21293 WP_011355140.1 NC_007511:c1732624-1732328 [Burkholderia lata]
MEKRTPHCKLLRVKALVESGKVRLTTSAVLGARQLGFTEREALGVVLSLTDLDFHKSMTTYADHTIWQDVYRPFTVRGDV
YLKLTVIDDVLIVSFKER

Nucleotide

• Length: 297 bp

>T21293 NC_007511:c1732624-1732328 [Burkholderia lata]
ATGGAAAAGAGAACGCCTCATTGCAAGCTGCTTCGCGTCAAAGCGCTCGTCGAATCCGGCAAGGTCCGGTTGACCACGAG
TGCGGTACTCGGCGCTCGACAACTGGGTTTCACGGAAAGGGAGGCGCTCGGTGTCGTGCTGTCGCTGACCGATCTCGACT
TCCACAAGAGCATGACGACGTACGCCGACCACACGATCTGGCAGGACGTCTACCGGCCTTTCACGGTGCGCGGCGACGTG
TACCTGAAGCTGACGGTGATCGACGATGTGCTGATCGTGTCTTTCAAGGAGCGATAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14621.88 Da
• Isoelectric Point: 8.4816

>AT21293 WP_011355139.1 NC_007511:c1732325-1731924 [Burkholderia lata]
MKCPACGAAKLVRDTRDIPYTYKGQSTVVRDITGDFCPACGESVLDLDEATRLGEAITEFNKQVNATIVDPKYIAKVRKK
LRLDQREAAEIFGGGVNAFSRYETGKTNPPLALVKLLKLLDRHPDLLAEVRAA

Nucleotide

• Length: 402 bp

>AT21293 NC_007511:c1732325-1731924 [Burkholderia lata]
ATGAAGTGCCCTGCATGCGGTGCCGCCAAGCTGGTCCGCGACACGCGAGACATCCCTTATACCTATAAAGGCCAGTCGAC
TGTCGTCCGCGATATCACCGGCGATTTCTGCCCGGCCTGCGGGGAATCGGTCCTGGATCTCGACGAGGCGACCCGTCTCG
GCGAAGCGATCACCGAGTTCAACAAGCAGGTGAACGCCACCATCGTCGACCCGAAGTACATCGCGAAGGTGCGCAAGAAG
CTGAGGCTGGATCAGCGCGAGGCGGCCGAGATCTTCGGCGGCGGCGTCAACGCGTTCTCCCGTTACGAAACGGGCAAGAC
GAATCCGCCGCTCGCCCTCGTGAAATTGCTGAAGCTCCTGGATCGTCACCCCGATCTCCTCGCCGAAGTTCGAGCGGCAT
AG

Structures

Toxin

• AlphaFold DB: Q396G0

Antitoxin

• AlphaFold DB: Q396G1