Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1245937..1247687 Replicon chromosome
Accession NC_007511
Organism Burkholderia lata

Toxin (Protein)


Gene name doc Uniprot ID Q397Y9
Locus tag BCEP18194_RS28315 Protein ID WP_011354715.1
Coordinates 1245937..1246833 (+) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q397Y8
Locus tag BCEP18194_RS28320 Protein ID WP_011354716.1
Coordinates 1246830..1247687 (+) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCEP18194_RS28285 1241307..1242386 - 1080 WP_011354709.1 porin -
BCEP18194_RS28290 1242831..1243148 + 318 WP_011354710.1 non-heme iron oxygenase ferredoxin subunit -
BCEP18194_RS28295 1243150..1243461 + 312 WP_011354711.1 hypothetical protein -
BCEP18194_RS28300 1243514..1244590 + 1077 WP_011354712.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
BCEP18194_RS28305 1244583..1245353 + 771 WP_011354713.1 SDR family oxidoreductase -
BCEP18194_RS28310 1245391..1245918 + 528 WP_011354714.1 cupin domain-containing protein -
BCEP18194_RS28315 1245937..1246833 + 897 WP_011354715.1 alpha/beta fold hydrolase Toxin
BCEP18194_RS28320 1246830..1247687 + 858 WP_011354716.1 IclR family transcriptional regulator Antitoxin
BCEP18194_RS28325 1247684..1248481 + 798 WP_011354717.1 SDR family oxidoreductase -
BCEP18194_RS28330 1248474..1250141 + 1668 WP_011354718.1 thiamine pyrophosphate-binding protein -
BCEP18194_RS28335 1250134..1250949 + 816 WP_011354719.1 aspartate dehydrogenase -
BCEP18194_RS28340 1251022..1252512 + 1491 WP_011354720.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-279)

Antitoxin

Transcription regulator IclR, C-terminal

(143-266)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30736.03 Da        Isoelectric Point: 8.3523

>T21292 WP_011354715.1 NC_007511:1245937-1246833 [Burkholderia lata]
MSVIDKRERDRTAAFAALLGQFPEQRCVAGAAGTIGYREAGAQHAGRALPVVLLHGIGSGAASWVRQLDTLGASRRVLAW
DAPGYGVSTPVRGASPAAADYAASLNAWLEALGIERCVLVGHSLGAIIAGGLARVMPARIAGLLLVSPAGGYGSAPAETR
ESRRDARLAMLAELGPAGLAEQRSGNMLSGFANEDARAWVRWNMARIVPAGYAQATHLLANADLATDLAGFRGRTAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAVYSALIDTFCRQCDQQRGLA

Download         Length: 897 bp

>T21292 NC_007511:1245937-1246833 [Burkholderia lata]
ATGAGTGTCATCGACAAACGTGAACGCGACCGCACCGCGGCGTTCGCCGCGCTGCTCGGGCAGTTTCCCGAACAGCGTTG
CGTGGCCGGCGCGGCGGGCACGATCGGTTATCGCGAGGCCGGCGCGCAGCATGCAGGCCGTGCGCTGCCCGTCGTGCTGC
TGCACGGCATCGGCTCGGGCGCCGCATCGTGGGTCCGCCAGCTCGACACGCTCGGCGCATCGCGGCGCGTGCTCGCGTGG
GATGCGCCCGGTTACGGCGTGTCGACGCCGGTGCGCGGTGCGTCGCCGGCCGCCGCCGATTACGCGGCATCGCTGAACGC
GTGGCTCGAGGCACTCGGCATCGAACGCTGCGTGCTGGTCGGTCATTCGCTCGGCGCGATCATCGCGGGCGGTCTTGCCC
GCGTGATGCCCGCGCGGATCGCCGGCCTGCTGCTGGTGTCGCCTGCGGGCGGCTACGGCAGCGCACCGGCCGAAACGCGC
GAATCGCGCCGCGATGCGCGGCTCGCGATGCTCGCCGAACTCGGTCCGGCCGGGCTCGCCGAGCAGCGCAGCGGCAACAT
GCTGTCCGGCTTCGCGAACGAGGATGCGCGTGCGTGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGCCGGTTATGCGC
AGGCCACGCATCTGCTCGCGAACGCCGATCTCGCAACGGATCTTGCCGGCTTTCGCGGCCGCACGGCCGTGGCCGTCGGC
GCGAACGACGCGATCACGCCGCCCGCCGCGTGCGAGCGGATTGCCGCGGCCGCGCACGTCGGGCTGCAGGTGATTCCGCA
AGCAGGCCATGCCGGCTACGTGGAAGCACCGGCCGTCTATTCCGCACTGATCGACACGTTCTGCCGTCAGTGCGACCAAC
AGCGGGGGCTGGCATGA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31368.82 Da        Isoelectric Point: 6.5058

>AT21292 WP_011354716.1 NC_007511:1246830-1247687 [Burkholderia lata]
MNEPLQQPDTENGKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQAPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELHALYPEGSLNRMTNATPESVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQKIVACITVTVP
RPEIDAALISDGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 858 bp

>AT21292 NC_007511:1246830-1247687 [Burkholderia lata]
ATGAACGAACCGCTGCAACAACCCGATACCGAAAACGGCAAGGCCGAAGCCAGCTACGTCGTGCCCGGCCTCGAGCGCGG
GCTGCGGATCCTCGCCGAATTCTCGCCGCGCGAGCCCGTGCTCGGCGCGCCCGAATTGTCGAAACGGCTCGGCATTCCGC
GCACGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTCGGCTTCCTCGAGCGGGCGGACAAGGATCGCAACTACAAG
CTCGGCATTGCCGTGCTGCGGCTCGGCTTCGAATACCTGAGCTCGCTGGAGCTGACCGATCTCGGCCTGCCGGTGATCGA
GAGCCTGCGCGACGCGACCGGCTTCACGACGCACATCGTGATCCGGGACGGCCGCGACGTGGTGTTCGTCGCGAAGGCGC
AGAGCCAGGCGCCGGTGTTCAGCTCGATCCGCGTGAACGTCGGCACGCGCTTGCCCGCGCATGCGACGACCCACGGCCAC
GTGCTGATGGGCGACCTGTCGCTGAAGGAGCTGCATGCGCTGTATCCGGAAGGTTCATTGAACCGGATGACGAACGCGAC
GCCGGAGTCGGTCGACGCACTGTACGAAGTGATCCGCGAGGATGCGCTGCGCGGTTACGGCGTCAGCAACTCGTCGTTCG
AGCGCGGCATCTCGGTGGTCACGGCGCCGGTGCGAAACGAAACGCAGAAGATCGTCGCGTGCATTACGGTGACGGTGCCG
CGCCCGGAAATCGACGCGGCGCTGATCTCGGACGGTCTGATCGACAAGGTGCAGCGCGCAGCGGCAGAACTGTCGCGGCG
GCTCAATTACCGCTCGGATGACGAGCACACGTTTCTCAAGGCTTTAGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q397Y9

Antitoxin

Source ID Structure
AlphaFold DB Q397Y8

References