Detailed information of TA system TA021291

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 1006769..1007424
• Replicon: chromosome
• Accession: NC_007511
• Organism: Burkholderia lata

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q398V1
• Locus tag: BCEP18194_RS27240
• Protein ID: WP_011354503.1
• Coordinates: 1007005..1007424 (+)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: BCEP18194_RS27235
• Protein ID: WP_041493225.1
• Coordinates: 1006769..1007008 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-122)

Antitoxin

• Arc-like DNA binding domain (7-46)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15146.41 Da
• Isoelectric Point: 5.2065

>T21291 WP_011354503.1 NC_007511:1007005-1007424 [Burkholderia lata]
MILVDTNVMSEPLRREPSAAVIEWLDAQNVETLFLAAISLGEMRFGVAAMPEGRRRDWLHQSIEQRVVPLFRGRILPFDD
AASKAYSSIRARARASGSAIAPADVFIAATAEANGLIIATRDVAPFEAVGLRVIDPWAS

Nucleotide

• Length: 420 bp

>T21291 NC_007511:1007005-1007424 [Burkholderia lata]
ATGATCCTTGTTGATACGAACGTGATGTCCGAGCCGCTGAGGCGCGAGCCGAGCGCAGCCGTGATCGAGTGGCTCGATGC
CCAGAACGTCGAAACGTTGTTTCTTGCCGCGATCAGTCTCGGCGAAATGCGCTTCGGCGTGGCGGCAATGCCGGAAGGGC
GCAGGCGTGACTGGCTTCACCAAAGCATCGAGCAGCGCGTCGTGCCGCTGTTTCGCGGCAGGATTCTGCCGTTCGACGAT
GCGGCGAGCAAAGCGTATTCGAGCATTCGAGCGCGGGCGCGTGCCTCAGGCAGTGCGATCGCGCCTGCCGATGTTTTTAT
CGCCGCGACGGCCGAGGCGAACGGATTGATCATTGCGACGCGCGACGTCGCGCCATTCGAGGCGGTCGGCCTGCGGGTGA
TTGATCCATGGGCGTCCTAG

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8732.99 Da
• Isoelectric Point: 6.4654

>AT21291 WP_041493225.1 NC_007511:1006769-1007008 [Burkholderia lata]
MPVITVRNLPDEVHRALRIRAAQHGRSTEAEVRNILEQAVLPGGRLKLGTLLAEIGREAGGVDFDVQRDKTLTDPMSFE

Nucleotide

• Length: 240 bp

>AT21291 NC_007511:1006769-1007008 [Burkholderia lata]
ATGCCCGTGATTACCGTTCGAAATCTGCCCGACGAAGTGCACCGTGCGCTCCGAATCCGCGCGGCCCAGCATGGGCGCAG
CACAGAAGCCGAGGTGCGTAACATCCTCGAGCAGGCCGTTCTGCCGGGTGGCAGGCTGAAGCTTGGGACACTGCTGGCGG
AAATCGGACGGGAAGCGGGAGGCGTCGATTTCGACGTTCAGCGCGACAAGACGCTAACCGACCCGATGAGCTTCGAATGA

Structures

Toxin

• AlphaFold DB: Q398V1