Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-RelB
Location 950104..950627 Replicon chromosome
Accession NC_007511
Organism Burkholderia lata

Toxin (Protein)


Gene name relE Uniprot ID Q399A4
Locus tag BCEP18194_RS26995 Protein ID WP_011354451.1
Coordinates 950104..950370 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q399A3
Locus tag BCEP18194_RS27000 Protein ID WP_011354452.1
Coordinates 950367..950627 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCEP18194_RS26970 945869..946783 + 915 WP_011354446.1 LysR family transcriptional regulator -
BCEP18194_RS26975 946838..947437 + 600 WP_011354447.1 GNAT family N-acetyltransferase -
BCEP18194_RS26980 947551..948129 - 579 WP_011354448.1 DUF4142 domain-containing protein -
BCEP18194_RS26985 948531..949154 - 624 WP_011354449.1 HAD hydrolase-like protein -
BCEP18194_RS26990 949172..950002 - 831 WP_011354450.1 substrate-binding domain-containing protein -
BCEP18194_RS26995 950104..950370 - 267 WP_011354451.1 Txe/YoeB family addiction module toxin Toxin
BCEP18194_RS27000 950367..950627 - 261 WP_011354452.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
BCEP18194_RS27005 950853..951296 + 444 WP_011354453.1 GNAT family N-acetyltransferase -
BCEP18194_RS27010 951354..951572 + 219 WP_006480837.1 DUF1653 domain-containing protein -
BCEP18194_RS27015 951624..952835 - 1212 WP_011354454.1 winged helix-turn-helix domain-containing protein -
BCEP18194_RS27020 953209..954597 - 1389 WP_050781615.1 MFS transporter -
BCEP18194_RS40235 954624..954938 - 315 WP_081436659.1 hypothetical protein -
BCEP18194_RS41365 954966..955121 - 156 WP_157687248.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10526.86 Da        Isoelectric Point: 7.9861

>T21290 WP_011354451.1 NC_007511:c950370-950104 [Burkholderia lata]
MSVRRVLFTSDAWDDYVYWQGQDRKTLKRINQLIREAQRTPFEGIGKPEPLKANLSGFWSRRIDDTNRLVYEADDLQISI
VSCRYHYE

Download         Length: 267 bp

>T21290 NC_007511:c950370-950104 [Burkholderia lata]
ATGAGCGTACGCCGCGTGCTCTTTACCTCCGACGCGTGGGACGACTATGTCTACTGGCAGGGGCAGGATCGCAAGACGCT
CAAGCGCATCAACCAGCTCATTCGCGAAGCCCAGCGAACGCCGTTCGAAGGCATCGGCAAACCCGAACCGTTAAAGGCCA
ATCTCTCCGGCTTCTGGTCGCGCCGTATCGACGACACGAACCGTCTGGTCTACGAAGCTGACGACTTGCAGATCAGCATC
GTGTCCTGCCGCTACCACTACGAATAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9700.99 Da        Isoelectric Point: 6.4814

>AT21290 WP_011354452.1 NC_007511:c950627-950367 [Burkholderia lata]
MRTIHFSDARGNLKTVIDQVVDDADVTLITRRDAPNAVIMSQDYYDSLMETVHLLRSPANVAHLERSIAQLRKGKAKEHK
LAADEE

Download         Length: 261 bp

>AT21290 NC_007511:c950627-950367 [Burkholderia lata]
ATGCGCACGATTCATTTTTCGGATGCTCGTGGCAATCTGAAGACGGTTATCGACCAGGTCGTCGACGATGCGGACGTAAC
GCTCATCACGCGCCGCGATGCACCGAACGCCGTCATCATGTCGCAGGACTACTACGACAGCCTGATGGAGACGGTGCACT
TGCTGCGCTCGCCGGCCAACGTCGCCCATCTCGAGCGTTCGATCGCGCAACTGCGCAAGGGCAAGGCGAAAGAACACAAG
CTCGCGGCGGATGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J9NJ39

Antitoxin

Source ID Structure
AlphaFold DB Q399A3

References