Detailed information of TA system TA021289

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 355050..355615
• Replicon: chromosome
• Accession: NC_007511
• Organism: Burkholderia lata

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q39AR6
• Locus tag: BCEP18194_RS24415
• Protein ID: WP_011353943.1
• Coordinates: 355050..355421 (-)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: Q39AR5
• Locus tag: BCEP18194_RS24420
• Protein ID: WP_011353944.1
• Coordinates: 355418..355615 (-)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BCEP18194_RS24400	350895..351620	+	726	WP_011353940.1	site-2 protease family protein	-
BCEP18194_RS24405	351699..353078	-	1380	WP_011353941.1	MFS transporter	-
BCEP18194_RS24410	353326..354903	+	1578	WP_011353942.1	aldehyde dehydrogenase (NADP(+))	-
BCEP18194_RS24415	355050..355421	-	372	WP_011353943.1	type II toxin-antitoxin system VapC family toxin	Toxin
BCEP18194_RS24420	355418..355615	-	198	WP_011353944.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
BCEP18194_RS24425	355897..356451	+	555	WP_011353945.1	hypothetical protein	-
BCEP18194_RS24430	356565..357479	-	915	WP_011353946.1	5-dehydro-4-deoxyglucarate dehydratase	-
BCEP18194_RS24435	357709..359262	+	1554	WP_011353947.1	galactarate dehydratase	-
BCEP18194_RS24440	359543..359944	+	402	WP_041493165.1	nuclear transport factor 2 family protein	-
BCEP18194_RS24445	360024..360479	+	456	WP_011353949.1	RbsD/FucU family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-110)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-46)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13356.39 Da
• Isoelectric Point: 6.2117

>T21289 WP_011353943.1 NC_007511:c355421-355050 [Burkholderia lata]
MILVDTSVWIDHLRAGDVTLTALLETDRVLIHPFVIGELALGSLRDRQTVLDALRDLPVATSATDDEVQRLVDVVPLHGL
GIGYVDAHLLASVRLTGGSKLWTRDRRLLSAADRLGLAAHPAH

Nucleotide

• Length: 372 bp

>T21289 NC_007511:c355421-355050 [Burkholderia lata]
ATGATTCTTGTCGACACCTCCGTCTGGATCGACCATCTTCGCGCCGGTGACGTCACGCTCACAGCGCTACTGGAAACCGA
CCGAGTACTGATCCATCCTTTCGTGATCGGCGAACTCGCGCTCGGCAGCCTGCGAGATCGCCAGACCGTACTGGATGCGC
TGCGCGATCTGCCCGTCGCCACCTCGGCAACTGACGATGAAGTTCAGCGCCTGGTCGATGTCGTGCCGCTTCACGGGCTC
GGCATCGGCTACGTCGATGCGCACCTGCTCGCCTCGGTCCGACTGACCGGTGGCAGCAAGCTGTGGACACGCGACCGGCG
CCTGCTGAGCGCAGCAGACCGCCTGGGGCTCGCTGCGCATCCCGCCCACTGA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7026.09 Da
• Isoelectric Point: 10.4525

>AT21289 WP_011353944.1 NC_007511:c355615-355418 [Burkholderia lata]
MRTTLSLDDALLAKAQQLTGVTEKSALVKEALRALIARESARRLARLGGTEPDLESIPRRPSDPA

Nucleotide

• Length: 198 bp

>AT21289 NC_007511:c355615-355418 [Burkholderia lata]
ATGCGCACGACCTTGTCCCTTGACGACGCCCTGCTTGCCAAAGCGCAGCAATTGACCGGCGTGACCGAAAAATCAGCCTT
GGTGAAAGAGGCGCTGCGCGCGTTGATCGCCCGCGAAAGCGCCCGTCGGCTCGCCCGACTCGGCGGCACCGAGCCTGATC
TCGAATCCATCCCGCGCCGCCCGTCGGACCCAGCATGA

Structures

Toxin

• AlphaFold DB: Q39AR6

Antitoxin

• AlphaFold DB: Q39AR5