Detailed information of TA system TA021288

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbE-relB/ParE-YafN
• Location: 169722..170241
• Replicon: chromosome
• Accession: NC_007511
• Organism: Burkholderia lata

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: -
• Locus tag: BCEP18194_RS23550
• Protein ID: WP_041493151.1
• Coordinates: 169993..170241 (+)
• Length: 83 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q39B90
• Locus tag: BCEP18194_RS23545
• Protein ID: WP_011353769.1
• Coordinates: 169722..169970 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BCEP18194_RS23525	165472..166692	-	1221	WP_011353765.1	CoA transferase	-
BCEP18194_RS23530	166757..167539	-	783	WP_011353766.1	crotonase/enoyl-CoA hydratase family protein	-
BCEP18194_RS23535	167674..168441	+	768	WP_011353767.1	helix-turn-helix domain-containing protein	-
BCEP18194_RS23540	168528..169580	+	1053	WP_011353768.1	CoA transferase	-
BCEP18194_RS23545	169722..169970	+	249	WP_011353769.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
BCEP18194_RS23550	169993..170241	+	249	WP_041493151.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BCEP18194_RS23555	170359..170802	-	444	WP_011353771.1	PaaI family thioesterase	-
BCEP18194_RS23560	171073..172692	+	1620	WP_011353772.1	Tar ligand binding domain-containing protein	-
BCEP18194_RS23565	172665..173774	-	1110	WP_011353773.1	AGE family epimerase/isomerase	-
BCEP18194_RS23570	173889..174587	+	699	WP_041493152.1	MgtC/SapB family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-73)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 83 a.a.
• Molecular weight: 9681.37 Da
• Isoelectric Point: 11.0736

>T21288 WP_041493151.1 NC_007511:169993-170241 [Burkholderia lata]
MKAWTMLDRTVRDQFKSRLAERLENPRIPSAKLHGHPDRYKIKLRSVGYRLVYEVRDSEVLVLVVAVGRRERDAVYLAAM
KR

Nucleotide

• Length: 249 bp

>T21288 NC_007511:169993-170241 [Burkholderia lata]
TTGAAGGCGTGGACGATGCTCGATCGCACCGTTCGCGACCAGTTCAAATCCCGGCTCGCCGAGCGGCTCGAGAATCCTCG
GATTCCGTCTGCAAAGCTGCATGGCCATCCGGATCGCTACAAGATCAAGCTACGCAGCGTCGGTTACCGGCTCGTCTACG
AAGTGCGCGATTCGGAAGTGCTCGTACTGGTCGTGGCGGTCGGTCGACGCGAGCGCGATGCGGTCTATCTTGCCGCGATG
AAGCGTTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9142.56 Da
• Isoelectric Point: 5.1086

>AT21288 WP_011353769.1 NC_007511:169722-169970 [Burkholderia lata]
MPRTILADFTASVSDLKRNPIGTVAAGEGFPVAILNRNEPAFYCVPAKTWEVMVERLEDIEDNGLVDKRANERVVKVKLK
DL

Nucleotide

• Length: 249 bp

>AT21288 NC_007511:169722-169970 [Burkholderia lata]
ATGCCTCGCACAATTCTGGCCGACTTTACCGCGAGCGTTTCAGATTTGAAGCGGAACCCGATAGGCACGGTCGCGGCGGG
AGAAGGCTTCCCGGTCGCGATTCTGAATCGCAACGAGCCCGCGTTCTATTGCGTCCCGGCGAAGACGTGGGAGGTGATGG
TCGAACGTCTGGAGGATATCGAAGACAACGGGCTGGTCGACAAGCGCGCCAATGAGAGAGTCGTCAAAGTCAAGCTGAAG
GACCTTTGA

Structures

Antitoxin

• AlphaFold DB: Q39B90