Detailed information of TA system TA021286

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-vagC/VapC-VagC
• Location: 165403..166040
• Replicon: chromosome
• Accession: NC_007510
• Organism: Burkholderia lata

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q39KU4
• Locus tag: BCEP18194_RS06650
• Protein ID: WP_011350558.1
• Coordinates: 165639..166040 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: -
• Locus tag: BCEP18194_RS06645
• Protein ID: WP_041492713.1
• Coordinates: 165403..165639 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BCEP18194_RS06630	160889..161923	+	1035	WP_011350554.1	helix-turn-helix domain-containing protein	-
BCEP18194_RS06635	162244..163341	-	1098	WP_011350555.1	hypothetical protein	-
BCEP18194_RS06640	163338..165041	-	1704	WP_011350556.1	thiamine pyrophosphate-binding protein	-
BCEP18194_RS06645	165403..165639	+	237	WP_041492713.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
BCEP18194_RS06650	165639..166040	+	402	WP_011350558.1	type II toxin-antitoxin system VapC family toxin	Toxin
BCEP18194_RS06655	166108..167496	-	1389	WP_011350559.1	L-serine ammonia-lyase	-
BCEP18194_RS06660	167527..168663	-	1137	WP_011350560.1	alginate lyase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-121)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14885.91 Da
• Isoelectric Point: 4.7145

>T21286 WP_011350558.1 NC_007510:165639-166040 [Burkholderia lata]
MARYMLDTNMCLYLMKNQPEQVARRFAQCYTGDVVMSAITYAELEYGVTACASPARERGNLAALIDDIPVAPFDVAAAQA
YGPVREATRDRKKDHLDKLIAAHAVSLDVVLVTNNERDFDSYPGLRLENWLND

Nucleotide

• Length: 402 bp

>T21286 NC_007510:165639-166040 [Burkholderia lata]
ATGGCGCGCTACATGCTCGACACCAACATGTGCCTCTACCTGATGAAGAATCAGCCGGAGCAGGTTGCGAGACGATTTGC
GCAGTGCTACACGGGGGACGTCGTGATGTCGGCGATCACGTACGCCGAACTCGAGTACGGCGTCACCGCGTGCGCGAGTC
CAGCGCGGGAGCGCGGCAATCTTGCCGCGCTGATCGACGATATTCCGGTCGCGCCGTTCGACGTCGCGGCTGCGCAAGCG
TACGGCCCGGTCCGCGAGGCAACCCGCGATCGGAAGAAGGATCACCTCGACAAGCTGATCGCCGCACACGCGGTGTCGCT
CGATGTCGTCCTCGTGACCAACAACGAGCGGGATTTCGACAGCTATCCGGGATTGCGGCTGGAAAACTGGCTGAACGACT
AG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8980.07 Da
• Isoelectric Point: 5.7252

>AT21286 WP_041492713.1 NC_007510:165403-165639 [Burkholderia lata]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERIGDEIRIRPARRPLTNVLDKFAKFGPDFMAEGRGDHEQAEREGL

Nucleotide

• Length: 237 bp

>AT21286 NC_007510:165403-165639 [Burkholderia lata]
ATGCATACGACGAGGGTATTTCGGAACGGCAACTCGCAGGCTGTGCGAATTCCTGCCGACCTTGCCTATGAGCGCAGTGA
TATCGAACTGGAAATCGAGCGCATCGGTGACGAAATCCGTATTCGGCCGGCGCGGCGGCCTTTGACGAACGTCCTCGATA
AGTTCGCGAAATTCGGGCCGGATTTCATGGCCGAAGGGCGTGGCGACCACGAGCAGGCCGAACGCGAGGGTTTGTGA

Structures

Toxin

• AlphaFold DB: Q39KU4