Detailed information of TA system TA212753

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yhaV-relB/YhaV(toxin)
• Location: 160080..160897
• Replicon: plasmid unnamed1
• Accession: NZ_CP081244
• Organism: Phaeobacter inhibens strain M633

Toxin (Protein)

• Gene name: yhaV
• Uniprot ID: -
• Locus tag: K4L04_RS19185
• Protein ID: WP_260081241.1
• Coordinates: 160379..160897 (-)
• Length: 173 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: K4L04_RS19180
• Protein ID: WP_260081240.1
• Coordinates: 160080..160232 (-)
• Length: 51 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K4L04_RS19170 (K4L04_19185)	155211..155597	-	387	WP_260081238.1	hypothetical protein	-
K4L04_RS19175 (K4L04_19190)	155719..159978	-	4260	WP_260081239.1	strawberry notch family protein	-
K4L04_RS19180 (K4L04_19195)	160080..160232	-	153	WP_260081240.1	StaA	Antitoxin
K4L04_RS19185 (K4L04_19200)	160379..160897	-	519	WP_260081241.1	type II toxin-antitoxin system YhaV family toxin	Toxin
K4L04_RS19190 (K4L04_19205)	160894..161220	-	327	WP_260081242.1	type II toxin-antitoxin system PrlF family antitoxin	-
K4L04_RS19195 (K4L04_19210)	161346..161999	-	654	WP_260081322.1	hypothetical protein	-
K4L04_RS19200 (K4L04_19215)	161999..162592	-	594	WP_260081243.1	regulator	-
K4L04_RS19205 (K4L04_19220)	162669..164651	-	1983	WP_260081244.1	ParB/RepB/Spo0J family partition protein	-
K4L04_RS19210 (K4L04_19225)	164810..165199	-	390	WP_102859864.1	DUF3768 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..183140	183140

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin endonuclease, YhaV (19-155)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 173 a.a.
• Molecular weight: 19340.00 Da
• Isoelectric Point: 9.2700

>T212753 WP_260081241.1 NZ_CP081244:c160897-160379 [Phaeobacter inhibens]
MTGDSVPAQAPLVVNGWSIYAHPLFLDQLEGLIEEVEARKARDPKTWRKKNPTKRLAAIFKLVTEAIPADPGAAAFRQGG
TLGDHRKHWFRAKFFQQYRLFYRFNSDAKVIVVAWVNDDKTLRAYGSKTDAYATFKGMLDNGNPPDNFDVLLKEAAAAHE
GFEMSLEAVPDR

Nucleotide

• Length: 519 bp

>T212753 NZ_CP107346:18105-18575 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
TTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAACTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin

Protein

• Length: 51 a.a.
• Molecular weight: 5360.95 Da
• Isoelectric Point: 6.0760

>AT212753 WP_260081240.1 NZ_CP081244:c160232-160080 [Phaeobacter inhibens]
VAADVNSYDAWFRAQLQAALDDARAGTSQVQVMQAAQALIDAKRQGQSKP

Nucleotide

• Length: 153 bp

>AT212753 NZ_CP107346:17665-18108 [Klebsiella pneumoniae]
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTTCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGCGAATCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACGTTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACAGGAGCGTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA