Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2883448..2883950 Replicon chromosome
Accession NZ_CP081202
Organism Pseudomonas aeruginosa strain P9W

Toxin (Protein)


Gene name yoeB Uniprot ID A0A1C7CBF7
Locus tag K3176_RS13700 Protein ID WP_023081358.1
Coordinates 2883448..2883702 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1C7C600
Locus tag K3176_RS13705 Protein ID WP_004350479.1
Coordinates 2883699..2883950 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3176_RS13680 (K3176_13680) 2879883..2880746 + 864 WP_004350470.1 integrase domain-containing protein -
K3176_RS13685 (K3176_13685) 2880934..2881284 + 351 WP_023081356.1 hypothetical protein -
K3176_RS13690 (K3176_13690) 2881299..2882819 + 1521 WP_004350477.1 conjugal transfer protein TraG N-terminal domain-containing protein -
K3176_RS13695 (K3176_13695) 2882827..2883222 - 396 WP_023081357.1 DUF3742 family protein -
K3176_RS13700 (K3176_13700) 2883448..2883702 - 255 WP_023081358.1 Txe/YoeB family addiction module toxin Toxin
K3176_RS13705 (K3176_13705) 2883699..2883950 - 252 WP_004350479.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
K3176_RS13710 (K3176_13710) 2884173..2885405 - 1233 Protein_2723 tyrosine-type recombinase/integrase -
K3176_RS13720 (K3176_13720) 2886194..2886694 - 501 WP_003098996.1 DUF305 domain-containing protein -
K3176_RS13725 (K3176_13725) 2887145..2887891 + 747 WP_003098991.1 hypothetical protein -
K3176_RS13730 (K3176_13730) 2888010..2888222 + 213 WP_003090093.1 AlpA family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10061.50 Da        Isoelectric Point: 8.4789

>T212743 WP_023081358.1 NZ_CP081202:c2883702-2883448 [Pseudomonas aeruginosa]
VKLIWSEQAWDDYLYWQDTDKRMVKKVNELIKDACRTPFEGKGKPEPLRHNLAGFWSRRITAEHRFVYSVTDDALLIAAC
RYHY

Download         Length: 255 bp

>T212743 NZ_CP107345:354089-354436 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9363.65 Da        Isoelectric Point: 4.5843

>AT212743 WP_004350479.1 NZ_CP081202:c2883950-2883699 [Pseudomonas aeruginosa]
MRTISYTEARQNLSATMMKTVEDRAPILITRQNGEACVLMSLEEFNALEETAYLLRSPANARRLMDSIDSLKQGQGVERD
LAE

Download         Length: 252 bp

>AT212743 NZ_CP107345:354436-354735 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1C7CBF7

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7C600

References