Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RHH
Location 479999..480521 Replicon chromosome
Accession NC_007484
Organism Nitrosococcus oceani ATCC 19707

Toxin (Protein)


Gene name relE Uniprot ID A0A0E2ZQ40
Locus tag NOC_RS02480 Protein ID WP_002813622.1
Coordinates 479999..480289 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q3JDX7
Locus tag NOC_RS02485 Protein ID WP_002812536.1
Coordinates 480279..480521 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOC_RS02445 475351..475644 - 294 WP_036497897.1 HigA family addiction module antidote protein -
NOC_RS02450 475644..475922 - 279 WP_011330341.1 type II toxin-antitoxin system RelE/ParE family toxin -
NOC_RS02455 476041..477645 - 1605 WP_011330342.1 type I restriction-modification system subunit M -
NOC_RS02460 477642..478046 - 405 WP_002812854.1 tRNA(fMet)-specific endonuclease VapC -
NOC_RS02465 478046..478276 - 231 WP_002812508.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
NOC_RS02470 478400..479554 - 1155 WP_011330343.1 transposase -
NOC_RS02475 479590..479742 + 153 WP_036497902.1 CopG family transcriptional regulator -
NOC_RS17235 479823..479963 - 141 WP_011330344.1 hypothetical protein -
NOC_RS02480 479999..480289 - 291 WP_002813622.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NOC_RS02485 480279..480521 - 243 WP_002812536.1 CopG family ribbon-helix-helix protein Antitoxin
NOC_RS02490 480607..481899 - 1293 WP_197538940.1 restriction endonuclease subunit S -
NOC_RS02495 481904..482395 - 492 WP_002813653.1 hypothetical protein -
NOC_RS02500 482374..484992 - 2619 WP_002813747.1 type I restriction endonuclease subunit R -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 473378..484992 11614


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-29)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10943.57 Da        Isoelectric Point: 10.1507

>T21267 WP_002813622.1 NC_007484:c480289-479999 [Nitrosococcus oceani ATCC 19707]
VEVKWLNKALQNLDAEAAYIAQDNPAAARRVVQTIVDAINLLSDNPALGRPGRVPGTRELVVADTHYLVPYRVRPRLQQI
EVLRVFHTSRRLPEHW

Download         Length: 291 bp

>T21267 NC_007484:c480289-479999 [Nitrosococcus oceani ATCC 19707]
GTGGAAGTTAAGTGGTTGAACAAGGCATTGCAAAACCTTGATGCGGAAGCCGCCTATATTGCTCAAGACAACCCGGCCGC
CGCCAGGCGGGTGGTGCAAACCATTGTGGATGCCATCAACTTGCTGTCCGATAATCCGGCGCTGGGCCGACCAGGCCGAG
TGCCGGGTACGCGTGAACTGGTGGTTGCTGATACGCACTATCTTGTGCCCTATCGCGTGAGGCCGCGCCTGCAACAGATC
GAGGTTCTGCGTGTGTTTCATACCTCAAGGCGTTTGCCCGAGCATTGGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8995.17 Da        Isoelectric Point: 5.0190

>AT21267 WP_002812536.1 NC_007484:c480521-480279 [Nitrosococcus oceani ATCC 19707]
MTTTMTLRLDPELKNRLDQLAKAMHRSKSFLAVQALQDFIELNEWQVGEIESAIKEADQGDFASQQAVSQTLSKWRVGGS

Download         Length: 243 bp

>AT21267 NC_007484:c480521-480279 [Nitrosococcus oceani ATCC 19707]
ATGACCACAACCATGACATTGCGCCTTGATCCGGAACTCAAAAATCGCCTGGATCAGTTGGCTAAGGCGATGCACCGTTC
CAAATCTTTTCTTGCCGTGCAGGCGTTGCAAGACTTTATCGAGCTGAACGAATGGCAGGTAGGCGAAATAGAAAGCGCTA
TCAAGGAAGCCGACCAGGGCGACTTTGCCTCGCAACAGGCTGTCAGCCAAACCCTGAGTAAGTGGCGAGTGGGTGGAAGT
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E2ZQ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E2Z4A9

References