Detailed information of TA system TA212619

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 1348314..1348519
• Replicon: chromosome
• Accession: NZ_CP081023
• Organism: Clostridioides difficile strain CD060

Toxin (Protein)

• Gene name: CD1233.1
• Uniprot ID: A0A069A9H6
• Locus tag: K2216_RS06330
• Protein ID: WP_009896140.1
• Coordinates: 1348314..1348466 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	SQ808
Locus tag	-
Coordinates	1348446..1348519 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K2216_RS06310 (1343783)	1343783..1344067	-	285	WP_003419254.1	sigma-70 family RNA polymerase sigma factor	-
K2216_RS06315 (1344090)	1344090..1345607	-	1518	WP_021362467.1	recombinase family protein	-
K2216_RS06320 (1345732)	1345732..1346553	-	822	WP_114086324.1	tetratricopeptide repeat protein	-
K2216_RS06325 (1346744)	1346744..1348171	+	1428	WP_114086323.1	cell wall-binding protein Cwp26	-
K2216_RS06330 (1348314)	1348314..1348466	+	153	WP_009896140.1	hypothetical protein	Toxin
- (1348446)	1348446..1348519	-	74	NuclAT_3	-	Antitoxin
- (1348446)	1348446..1348519	-	74	NuclAT_3	-	Antitoxin
- (1348446)	1348446..1348519	-	74	NuclAT_4	-	Antitoxin
K2216_RS06335 (1349500)	1349500..1349724	-	225	WP_003433396.1	helix-turn-helix transcriptional regulator	-
K2216_RS06340 (1350414)	1350414..1350569	+	156	WP_003433394.1	hypothetical protein	-
K2216_RS06345 (1350848)	1350848..1351066	+	219	WP_009889000.1	hypothetical protein	-
K2216_RS06350 (1352286)	1352286..1352669	-	384	WP_003433385.1	hypothetical protein	-
K2216_RS06355 (1352796)	1352796..1353140	+	345	WP_003433383.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5811.96 Da
• Isoelectric Point: 11.1039

>T212619 WP_009896140.1 NZ_CP081023:1348314-1348466 [Clostridioides difficile]
MDNFLFNVLASLTASVVVYLISKLFKKAKSHSRTKSDLRVEFKFIFKSKK

Nucleotide

• Length: 153 bp

>T212619 NZ_CP107297:4835807-4836340 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Nucleotide

• Length: 74 bp

>AT212619 NZ_CP081023:c1348519-1348446 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCGTTAGAGTGGAGTTCATCATAAACAGAGTTTATTTTTTGGATTTAAATAT

Structures

Toxin

• AlphaFold DB: A0A069A9H6

Antitoxin