Detailed information of TA system TA212523

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 1443183..1443403
• Replicon: chromosome
• Accession: NZ_CP081009
• Organism: Escherichia coli strain Stbl4

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: D3H2K1
• Locus tag: K3830_RS06885
• Protein ID: WP_000170955.1
• Coordinates: 1443183..1443290 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	1443337..1443403 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K3830_RS06860	1439027..1440109	+	1083	WP_000804726.1	peptide chain release factor 1	-
K3830_RS06865	1440109..1440942	+	834	WP_000456467.1	peptide chain release factor N(5)-glutamine methyltransferase	-
K3830_RS06870	1440939..1441331	+	393	WP_000200374.1	invasion regulator SirB2	-
K3830_RS06875	1441335..1442144	+	810	WP_001257044.1	invasion regulator SirB1	-
K3830_RS06880	1442180..1443034	+	855	WP_000811065.1	3-deoxy-8-phosphooctulonate synthase	-
K3830_RS06885	1443183..1443290	-	108	WP_000170955.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	1443337..1443403	+	67	-	-	Antitoxin
K3830_RS06890	1443720..1444856	+	1137	WP_000626848.1	protein YghO	-
K3830_RS06895	1444863..1445627	-	765	WP_001297764.1	transcriptional regulator GlcC	-
K3830_RS06900	1445878..1447377	+	1500	WP_000026083.1	glycolate oxidase subunit GlcD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4013.82 Da
• Isoelectric Point: 11.4779

>T212523 WP_000170955.1 NZ_CP081009:c1443290-1443183 [Escherichia coli]
MTLAQFAMIFWHDLAAPILAGIITAAIVSWWRNRK

Nucleotide

• Length: 108 bp

>T212523 NZ_CP107244:c5839075-5837762 [Achromobacter sp. SS2-2022]
ATGAACGGCGAATTCGTCGGCACCTGGAGCGTGCAACCGCATGTCGGAGAAGTCCTGCAGTATGCCGACGCCTGGGTGGC
ATCCGGACAGGGGCGCCCGCTGTCGCTGTCCCTCCCCTTCACCCCGGGCAATCCGCCGCACCGTGGCGAAGCCGTGCGCA
CCTACTTCGAAAACCTGCTGCCGGACAGCAAGGAAATCCGCGAGCGCGTGGCACGTCGGTACCAGGCCGGCTCGACCAAT
GCGTTCGCCTTGCTGGCTGAAGTTGGTCGGGACTGTGTCGGCGCGCTGCAGGTGGTGCCGGGCCCCGATGCGCCGGACGG
CGTGCAAGAGGTGAACGCGGTTCCGATGACCGACGCCGAGATTGCCCAGCTGCTTCGCAACACCCTGGCGCCAGGCCCCC
TGGGCCGGAACGCTGCCGAGGATGAAGACTTCCGCATCTCCATTGCCGGAGCACAGGAAAAGTCGGCCATGCTCTGGTAC
GACGGGCGGTGGTGCCGGCCGCATGGCGCGACACCGACCACTCACATCTTCAAGCTGCCACTGGGCCTGGTCGCAAACAT
GAAGTTCGACATGAGCGATTCGGTCGAAAACGAGTGGCTGTGCTCCGAAATCCTGCGCGCCTACCAAATGCCTGTGGCGC
GCACCGAGCCCCTGATGTTCGAGGACATGAAGGTGCTGGCGGTCGAGCGCTTCGACCGGATGTGGTGGGAGAGCCCAGAG
GGCAAGCGCTGGCTCATCCGGCTGCCGCAGGAAGACATGTGCCAAGCGACGGCAACCCCGCCGCATTTGAAGTACGAGTC
CGACGGCGGGCCGGGTGTGCGCCAAATCATGAAGCTGTTGGCTACGTCGCGCGCGCCTGACCGCGACCGTCGCACGTTCT
TCCAGGCCCAGGTCCTCTTCTGGATGCTGCGTGCCACGGATGGCCACGCGAAGAACTTCAGCATTTTCCTGCGCCAGGGT
GGCACCTACGAACTCACCCCGCTGTACGACGTACTTTCCGCTTACCCCGTCATCGGCAAGGGTGCGAAAAAGCTGTCTCC
GTACGACGCCAAGATGGCCATGGCCGTGCGCTCGAAAAACCCCCACTGGGTCATGCGCGACATCCTGCGTCGGCACTGGA
TCGCCGTGGGCACCGAGCATGGCGTAGTGAATCCCGACGGTAAGGGGGTGGAGCATGTCCTCGACGACCTGGTGGCGCGC
ACGCCCGGGGTCGTGAAGGCCGTCCGCGCGCTACTGCCGGCGGGATTCCCCATGCACGTGGCCGACTGCATCCTCAACGG
CCTGCAAGAGGCCGCTGACCACCTGGCAGGTTAG

Antitoxin

Nucleotide

• Length: 67 bp

>AT212523 NZ_CP081009:1443337-1443403 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A829J2A9

Antitoxin