Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3210222..3210876 Replicon chromosome
Accession NC_007384
Organism Shigella sonnei Ss046

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag SSON_RS16875 Protein ID WP_000244777.1
Coordinates 3210222..3210629 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag SSON_RS16880 Protein ID WP_000354046.1
Coordinates 3210610..3210876 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSON_RS16855 (3206179) 3206179..3207912 - 1734 WP_000813167.1 single-stranded-DNA-specific exonuclease RecJ -
SSON_RS16860 (3207918) 3207918..3208628 - 711 WP_000715206.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
SSON_RS16865 (3208653) 3208653..3209549 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
SSON_RS16870 (3209661) 3209661..3210182 + 522 WP_001055874.1 flavodoxin FldB -
SSON_RS16875 (3210222) 3210222..3210629 - 408 WP_000244777.1 protein YgfX Toxin
SSON_RS16880 (3210610) 3210610..3210876 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
SSON_RS16885 (3211119) 3211119..3212099 + 981 WP_000886060.1 tRNA-modifying protein YgfZ -
SSON_RS16890 (3212295) 3212295..3212954 - 660 WP_000250274.1 hemolysin III family protein -
SSON_RS16895 (3213118) 3213118..3213429 - 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
SSON_RS16900 (3213474) 3213474..3214907 + 1434 WP_005137189.1 6-phospho-beta-glucosidase BglA -
SSON_RS16905 (3214964) 3214964..3215707 - 744 WP_000951937.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T21248 WP_000244777.1 NC_007384:c3210629-3210222 [Shigella sonnei Ss046]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T21248 NC_007384:c3210629-3210222 [Shigella sonnei Ss046]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT21248 WP_000354046.1 NC_007384:c3210876-3210610 [Shigella sonnei Ss046]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT21248 NC_007384:c3210876-3210610 [Shigella sonnei Ss046]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References