Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 2473535..2474549 Replicon chromosome
Accession NZ_CP080998
Organism Mycolicibacterium holsaticum DSM 44478 = JCM 12374

Toxin (Protein)


Gene name pezT Uniprot ID A0A1E3R3L7
Locus tag K3U96_RS11870 Protein ID WP_069408076.1
Coordinates 2473535..2474128 (-) Length 198 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID A0A1E3R531
Locus tag K3U96_RS11875 Protein ID WP_069408075.1
Coordinates 2474160..2474549 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3U96_RS26910 2471850..2472068 - 219 Protein_2343 FAD-dependent oxidoreductase -
K3U96_RS11865 (K3U96_11865) 2472089..2473315 - 1227 WP_220693140.1 prolyl oligopeptidase family serine peptidase -
K3U96_RS11870 (K3U96_11870) 2473535..2474128 - 594 WP_069408076.1 zeta toxin family protein Toxin
K3U96_RS11875 (K3U96_11875) 2474160..2474549 - 390 WP_069408075.1 hypothetical protein Antitoxin
K3U96_RS11880 (K3U96_11880) 2475109..2476119 - 1011 WP_003932518.1 zinc-binding dehydrogenase -
K3U96_RS11885 (K3U96_11885) 2476116..2477285 - 1170 WP_220693141.1 cytochrome P450 -
K3U96_RS11890 (K3U96_11890) 2477316..2478068 - 753 WP_220693142.1 SDR family oxidoreductase -
K3U96_RS11895 (K3U96_11895) 2478065..2479309 - 1245 WP_220693143.1 MBL fold metallo-hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-138)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 198 a.a.        Molecular weight: 21444.60 Da        Isoelectric Point: 9.7721

>T212404 WP_069408076.1 NZ_CP080998:c2474128-2473535 [Mycolicibacterium holsaticum DSM 44478 = JCM 12374]
VKRLDLVVGPNGAGKSTFIELTLAPLLPGSVVVNADEIAKQRWPDDPASHAYEAARIAAATRERLIELGESFIAETVFSH
PSKLELLYSAHLRGYSVVVHAVLIPEQLAVARVQHRVAAGGHSVPEAKIRERYQRLWALVALAAARADSATFYDNSGIRG
PRIVAQMAGGFVVGSLRWPQWTPAALTTCWPNPPDRR

Download         Length: 594 bp

>T212404 NZ_CP107009:255160-255357 [Halomonas sp. LR3S48]
CTGGCATGGGGTTATTATAACCCTAAAGAGCGCGGCAAGGAGCCGGAAGCGGATGGCTGGACGTTGGACCGAGTCAAGGG
GAGCCATCATCACTTTCGCCATCCATACAAGCCCGGCACCATCACCGTGCCTCACCCCAAGAAAGACCTGAAAAAGGGTT
TGATACAGGGAATCAGAAAACAAGCCGGCCTCAAGTGA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13631.90 Da        Isoelectric Point: 4.7352

>AT212404 WP_069408075.1 NZ_CP080998:c2474549-2474160 [Mycolicibacterium holsaticum DSM 44478 = JCM 12374]
MTETADRVTRFAADLLDSAAAEGARQSRSAKQQLDHWARVGRAVSGQHSAARRKVEAALSGATPLSELSAEEGVVFNAEI
SAAIQERLADTDYGATLAGRGITTVALNDDGELVQYRPDGTSSTLSDQR

Download         Length: 390 bp

>AT212404 NZ_CP107009:255396-255809 [Halomonas sp. LR3S48]
ATGCACTACCCCATTGCGATCGAGGTTGGCGACGAGCAGCACGCTTATGGCGTGGTCGTGCCCGATCTGCCGGGCTGCTT
CTCCGCTGGCGACACCTTCGACGGGGCAATCGCCAATGCCCGGGAGGCCATAGAAGGGCATCTCGAGAGCCTGGCGGAGC
ACGGCGATCCCATTCCCACCGCTACCGCCATCCAGCAGCATCTGGAAAATCCCGACTTCGCCGGGTGGATCTGGGCCGCG
GTCGAGATCGACATGACTCCCTACCTGGGCAAGAGTCACAAGATCAACGTCACCTTGCCCGATCTGCTGATCAAGCGTAT
CGACAGCACCGTAGCGAAGCACGGCGACTACAAGAGCCGTTCCGGTTTCCTGGCCCGGGCTGCGCTGCATGAACTCGAGC
GTCACGCCCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E3R3L7

Antitoxin

Source ID Structure
AlphaFold DB A0A1E3R531

References