Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4170725..4171344 Replicon chromosome
Accession NZ_CP080584
Organism Klebsiella pneumoniae strain C1398 mutant C1

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag K2X23_RS20765 Protein ID WP_002892050.1
Coordinates 4171126..4171344 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag K2X23_RS20760 Protein ID WP_002892066.1
Coordinates 4170725..4171099 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K2X23_RS20750 (K2X23_20705) 4165877..4167070 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
K2X23_RS20755 (K2X23_20710) 4167093..4170239 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit AcrB -
K2X23_RS20760 (K2X23_20715) 4170725..4171099 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
K2X23_RS20765 (K2X23_20720) 4171126..4171344 + 219 WP_002892050.1 HHA domain-containing protein Toxin
K2X23_RS20770 (K2X23_20725) 4171503..4172069 + 567 WP_002892030.1 maltose O-acetyltransferase -
K2X23_RS20775 (K2X23_20730) 4172041..4172181 - 141 WP_004147370.1 hypothetical protein -
K2X23_RS20780 (K2X23_20735) 4172202..4172672 + 471 WP_002892026.1 YlaC family protein -
K2X23_RS20785 (K2X23_20740) 4172647..4174098 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
K2X23_RS20790 (K2X23_20745) 4174199..4174897 + 699 WP_002892021.1 GNAT family protein -
K2X23_RS20795 (K2X23_20750) 4174894..4175034 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
K2X23_RS20800 (K2X23_20755) 4175034..4175297 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T212208 WP_002892050.1 NZ_CP080584:4171126-4171344 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T212208 NZ_CP106998:183125-183232 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT212208 WP_002892066.1 NZ_CP080584:4170725-4171099 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT212208 NZ_CP106998:c183077-183011 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References