Detailed information of TA system TA212173

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1614301..1614880
• Replicon: chromosome
• Accession: NZ_CP080566
• Organism: Staphylococcus aureus strain HL20835 isolate HL20835

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: JMO16_RS07895
• Protein ID: WP_001025401.1
• Coordinates: 1614635..1614880 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1614301..1614666 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMO16_RS07855 (1611045)	1611045..1611602	-	558	WP_000645045.1	DUF2815 family protein	-
JMO16_RS07860 (1611628)	1611628..1612794	-	1167	WP_000762525.1	DUF2800 domain-containing protein	-
JMO16_RS07865 (1612791)	1612791..1613153	-	363	WP_000279445.1	hypothetical protein	-
JMO16_RS07870 (1613168)	1613168..1613491	-	324	WP_000174995.1	hypothetical protein	-
JMO16_RS07875 (1613570)	1613570..1613731	-	162	WP_015986189.1	DUF1270 family protein	-
JMO16_RS07880 (1613743)	1613743..1614006	-	264	WP_044426023.1	helix-turn-helix domain-containing protein	-
JMO16_RS07885 (1614031)	1614031..1614246	-	216	WP_001097552.1	hypothetical protein	-
JMO16_RS07890 (1614301)	1614301..1614666	+	366	WP_001128433.1	hypothetical protein	Antitoxin
JMO16_RS07895 (1614635)	1614635..1614880	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
JMO16_RS07900 (1614936)	1614936..1615145	+	210	WP_000642492.1	hypothetical protein	-
JMO16_RS07905 (1615135)	1615135..1615278	-	144	WP_000939498.1	hypothetical protein	-
JMO16_RS07910 (1615293)	1615293..1615736	-	444	WP_000435360.1	hypothetical protein	-
JMO16_RS07915 (1615754)	1615754..1615978	-	225	WP_063653167.1	DUF739 family protein	-
JMO16_RS07920 (1616140)	1616140..1616520	+	381	WP_001089477.1	helix-turn-helix domain-containing protein	-
JMO16_RS07925 (1616542)	1616542..1617000	+	459	WP_001558059.1	hypothetical protein	-
JMO16_RS07930 (1617018)	1617018..1617339	+	322	Protein_1572	hypothetical protein	-
JMO16_RS07935 (1617368)	1617368..1617763	+	396	WP_000449655.1	hypothetical protein	-
JMO16_RS07940 (1617853)	1617853..1617999	+	147	WP_001795334.1	hypothetical protein	-
JMO16_RS07945 (1617996)	1617996..1618610	-	615	WP_000191464.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1574610..1637566	62956

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T212173 WP_001025401.1 NZ_CP080566:c1614880-1614635 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T212173 NZ_CP106996:2300493-2301815 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin

Nucleotide

• Length: 366 bp

>AT212173 NZ_CP080566:1614301-1614666 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin