Detailed information of TA system TA212147

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 2396759..2397338
• Replicon: chromosome
• Accession: NZ_CP080562
• Organism: Staphylococcus aureus strain HL21008

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: JMO08_RS12035
• Protein ID: WP_001025401.1
• Coordinates: 2397093..2397338 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2396759..2397124 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMO08_RS11995 (JMO08_002399)	2393503..2394060	-	558	WP_000645045.1	DUF2815 family protein	-
JMO08_RS12000 (JMO08_002400)	2394086..2395252	-	1167	WP_000762525.1	DUF2800 domain-containing protein	-
JMO08_RS12005 (JMO08_002401)	2395249..2395611	-	363	WP_000279445.1	hypothetical protein	-
JMO08_RS12010 (JMO08_002402)	2395626..2395949	-	324	WP_000174995.1	hypothetical protein	-
JMO08_RS12015 (JMO08_002403)	2396028..2396189	-	162	WP_015986189.1	DUF1270 family protein	-
JMO08_RS12020 (JMO08_002404)	2396201..2396464	-	264	WP_044426023.1	helix-turn-helix domain-containing protein	-
JMO08_RS12025 (JMO08_002405)	2396489..2396704	-	216	WP_001097552.1	hypothetical protein	-
JMO08_RS12030 (JMO08_002406)	2396759..2397124	+	366	WP_001128433.1	hypothetical protein	Antitoxin
JMO08_RS12035 (JMO08_002407)	2397093..2397338	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
JMO08_RS12040 (JMO08_002408)	2397394..2397603	+	210	WP_000642492.1	hypothetical protein	-
JMO08_RS12045 (JMO08_002409)	2397593..2397736	-	144	WP_000939498.1	hypothetical protein	-
JMO08_RS12050 (JMO08_002410)	2397751..2398194	-	444	WP_044414793.1	hypothetical protein	-
JMO08_RS12055 (JMO08_002411)	2398218..2398439	-	222	WP_031887876.1	DUF739 family protein	-
JMO08_RS12060 (JMO08_002412)	2398600..2399370	+	771	WP_031887877.1	S24 family peptidase	-
JMO08_RS12065 (JMO08_002413)	2399382..2399528	+	147	WP_001049401.1	hypothetical protein	-
JMO08_RS12070 (JMO08_002414)	2399525..2399710	+	186	WP_000109189.1	hypothetical protein	-
JMO08_RS12075 (JMO08_002415)	2399780..2399947	+	168	WP_000705241.1	hypothetical protein	-
JMO08_RS12080 (JMO08_002416)	2400087..2400791	+	705	WP_000440838.1	type II toxin-antitoxin system PemK/MazF family toxin	-
JMO08_RS12085 (JMO08_002417)	2401002..2402207	+	1206	WP_031766111.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hysA	2358808..2432999	74191

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T212147 WP_001025401.1 NZ_CP080562:c2397338-2397093 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T212147 NZ_CP106995:1967178-1967281 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Nucleotide

• Length: 366 bp

>AT212147 NZ_CP080562:2396759-2397124 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin