Detailed information of TA system TA212117

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2605082..2605266
• Replicon: chromosome
• Accession: NZ_CP080556
• Organism: Staphylococcus aureus strain HL17078

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: JMO10_RS13230
• Protein ID: WP_000482650.1
• Coordinates: 2605159..2605266 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2605082..2605142 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMO10_RS13215	2600612..2600779	-	168	WP_001790576.1	hypothetical protein	-
JMO10_RS13220	2601010..2602743	-	1734	WP_000486494.1	ABC transporter ATP-binding protein	-
JMO10_RS13225	2602768..2604531	-	1764	WP_001064838.1	ABC transporter ATP-binding protein	-
-	2605082..2605142	+	61	-	-	Antitoxin
JMO10_RS13230	2605159..2605266	-	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
JMO10_RS13235	2605400..2605786	-	387	WP_000779358.1	flippase GtxA	-
JMO10_RS13240	2606054..2607196	+	1143	WP_001176863.1	glycerate kinase	-
JMO10_RS13245	2607256..2607915	+	660	WP_000831298.1	membrane protein	-
JMO10_RS13250	2608097..2609308	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
JMO10_RS13255	2609431..2609904	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T212117 WP_000482650.1 NZ_CP080556:c2605266-2605159 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T212117 NZ_CP106994:977325-977660 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Nucleotide

• Length: 61 bp

>AT212117 NZ_CP080556:2605082-2605142 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin