Detailed information of TA system TA212107

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2138912..2139211
• Replicon: chromosome
• Accession: NZ_CP080556
• Organism: Staphylococcus aureus strain HL17078

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: JMO10_RS10710
• Protein ID: WP_011447039.1
• Coordinates: 2139035..2139211 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2138912..2138967 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMO10_RS10670	2134243..2134503	+	261	WP_001791826.1	hypothetical protein	-
JMO10_RS10675	2134556..2134906	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
JMO10_RS10680	2135591..2136040	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
JMO10_RS10685	2136135..2136470	-	336	Protein_2074	SH3 domain-containing protein	-
JMO10_RS10690	2137120..2137611	-	492	WP_000919350.1	staphylokinase	-
JMO10_RS10695	2137802..2138557	-	756	WP_000861038.1	CHAP domain-containing protein	-
JMO10_RS10700	2138569..2138823	-	255	WP_000611512.1	phage holin	-
JMO10_RS10705	2138875..2138982	+	108	WP_001791821.1	hypothetical protein	-
-	2138904..2139043	+	140	NuclAT_0	-	-
-	2138904..2139043	+	140	NuclAT_0	-	-
-	2138904..2139043	+	140	NuclAT_0	-	-
-	2138904..2139043	+	140	NuclAT_0	-	-
-	2138912..2138967	+	56	-	-	Antitoxin
JMO10_RS10710	2139035..2139211	-	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
JMO10_RS10715	2139361..2139657	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
JMO10_RS10720	2139715..2140002	-	288	WP_001040261.1	hypothetical protein	-
JMO10_RS10725	2140049..2140201	-	153	WP_001153681.1	hypothetical protein	-
JMO10_RS10730	2140191..2143976	-	3786	WP_000582165.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb	2134556..2179556	45000

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T212107 WP_011447039.1 NZ_CP080556:c2139211-2139035 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T212107 NZ_CP106988:454696-455085 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT212107 NZ_CP080556:2138912-2138967 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin