Detailed information of TA system TA212049

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 2171175..2171713
• Replicon: chromosome
• Accession: NZ_CP080550
• Organism: Staphylococcus aureus strain HL18883

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: A0A0H3K0C1
• Locus tag: JMO14_RS10870
• Protein ID: WP_001078344.1
• Coordinates: 2171175..2171501 (-)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: A0A0H3JSN0
• Locus tag: JMO14_RS10875
• Protein ID: WP_001058495.1
• Coordinates: 2171504..2171713 (-)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMO14_RS10845 (JMO14_002171)	2166399..2166740	-	342	WP_001190615.1	hypothetical protein	-
JMO14_RS10850 (JMO14_002172)	2167190..2167831	-	642	WP_001047698.1	hypothetical protein	-
JMO14_RS10855 (JMO14_002173)	2167828..2168208	-	381	WP_000356942.1	hypothetical protein	-
JMO14_RS10860 (JMO14_002174)	2168518..2170227	-	1710	WP_000447473.1	DUF927 domain-containing protein	-
JMO14_RS10865 (JMO14_002175)	2170241..2171110	-	870	WP_001002689.1	primase alpha helix C-terminal domain-containing protein	-
JMO14_RS10870 (JMO14_002176)	2171175..2171501	-	327	WP_001078344.1	DUF1474 family protein	Toxin
JMO14_RS10875 (JMO14_002177)	2171504..2171713	-	210	WP_001058495.1	hypothetical protein	Antitoxin
JMO14_RS10880 (JMO14_002178)	2171706..2171852	-	147	WP_000784885.1	hypothetical protein	-
JMO14_RS10885 (JMO14_002179)	2171849..2172166	-	318	WP_000481967.1	helix-turn-helix domain-containing protein	-
JMO14_RS10890 (JMO14_002180)	2172171..2172389	-	219	WP_000153640.1	helix-turn-helix transcriptional regulator	-
JMO14_RS10895 (JMO14_002181)	2172562..2173236	+	675	WP_000620857.1	helix-turn-helix transcriptional regulator	-
JMO14_RS10900 (JMO14_002182)	2173250..2174422	+	1173	WP_000179343.1	tyrosine-type recombinase/integrase	-
JMO14_RS10905 (JMO14_002183)	2174491..2176107	-	1617	WP_000240642.1	chaperonin GroEL	-
JMO14_RS10910 (JMO14_002184)	2176183..2176467	-	285	WP_000917289.1	co-chaperone GroES	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sell / sec / tsst-1 / groEL	2152790..2176467	23677

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-100)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 12968.26 Da
• Isoelectric Point: 4.3050

>T212049 WP_001078344.1 NZ_CP080550:c2171501-2171175 [Staphylococcus aureus]
MNREIKDLFSDLKLLKDSFEDLKDSNGWHFDELYPYEPNHVLNKDELIGEGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFYEIEKASSENFGEESDDAKNSIKVAE

Nucleotide

• Length: 327 bp

>T212049 NZ_CP106924:1808610-1808861 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8206.22 Da
• Isoelectric Point: 4.3718

>AT212049 WP_001058495.1 NZ_CP080550:c2171713-2171504 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVVNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT212049 NZ_CP106924:1808858-1809112 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Structures

Toxin

• AlphaFold DB: A0A0H3K0C1

Antitoxin

• AlphaFold DB: A0A0H3JSN0