Detailed information of TA system TA212027

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1652989..1653568
• Replicon: chromosome
• Accession: NZ_CP080548
• Organism: Staphylococcus aureus strain HL18888

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: JMO15_RS08030
• Protein ID: WP_001025401.1
• Coordinates: 1653323..1653568 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1652989..1653354 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMO15_RS07990 (1649733)	1649733..1650290	-	558	WP_000645045.1	DUF2815 family protein	-
JMO15_RS07995 (1650316)	1650316..1651482	-	1167	Protein_1581	DUF2800 domain-containing protein	-
JMO15_RS08000 (1651479)	1651479..1651841	-	363	WP_000279445.1	hypothetical protein	-
JMO15_RS08005 (1651856)	1651856..1652179	-	324	WP_000174995.1	hypothetical protein	-
JMO15_RS08010 (1652258)	1652258..1652419	-	162	WP_015986189.1	DUF1270 family protein	-
JMO15_RS08015 (1652431)	1652431..1652694	-	264	WP_044426023.1	helix-turn-helix domain-containing protein	-
JMO15_RS08020 (1652719)	1652719..1652934	-	216	WP_001097552.1	hypothetical protein	-
JMO15_RS08025 (1652989)	1652989..1653354	+	366	WP_001128433.1	hypothetical protein	Antitoxin
JMO15_RS08030 (1653323)	1653323..1653568	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
JMO15_RS08035 (1653624)	1653624..1653833	+	210	WP_000642492.1	hypothetical protein	-
JMO15_RS08040 (1653823)	1653823..1653966	-	144	WP_000939498.1	hypothetical protein	-
JMO15_RS08045 (1653981)	1653981..1654424	-	444	WP_000435360.1	hypothetical protein	-
JMO15_RS08050 (1654442)	1654442..1654666	-	225	WP_063653167.1	DUF739 family protein	-
JMO15_RS08055 (1654828)	1654828..1655208	+	381	WP_001089477.1	helix-turn-helix domain-containing protein	-
JMO15_RS08060 (1655230)	1655230..1655688	+	459	WP_001558059.1	hypothetical protein	-
JMO15_RS08065 (1655706)	1655706..1656027	+	322	Protein_1595	hypothetical protein	-
JMO15_RS08070 (1656056)	1656056..1656451	+	396	WP_000449655.1	hypothetical protein	-
JMO15_RS08075 (1656541)	1656541..1656687	+	147	WP_001795334.1	hypothetical protein	-
JMO15_RS08080 (1656684)	1656684..1657298	-	615	WP_000191464.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1613298..1671381	58083

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T212027 WP_001025401.1 NZ_CP080548:c1653568-1653323 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T212027 NZ_CP106912:c5074096-5073179 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT212027 NZ_CP080548:1652989-1653354 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin