Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2312318..2312999 Replicon chromosome
Accession NZ_CP080511
Organism Pseudomonas aeruginosa strain DJ06

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag K1T67_RS10680 Protein ID WP_015503432.1
Coordinates 2312318..2312683 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K1T67_RS10685 Protein ID WP_003145733.1
Coordinates 2312676..2312999 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K1T67_RS10650 (K1T67_10650) 2308314..2308748 - 435 WP_003116494.1 RidA family protein -
K1T67_RS10655 (K1T67_10655) 2308969..2309922 + 954 WP_003085661.1 LysR substrate-binding domain-containing protein -
K1T67_RS10660 (K1T67_10660) 2309895..2310779 - 885 WP_003114205.1 LysR family transcriptional regulator -
K1T67_RS10665 (K1T67_10665) 2310880..2311305 + 426 WP_003114206.1 VOC family protein -
K1T67_RS10670 (K1T67_10670) 2311336..2311608 - 273 WP_023104842.1 hypothetical protein -
K1T67_RS10675 (K1T67_10675) 2311815..2312054 + 240 WP_044060930.1 hypothetical protein -
K1T67_RS10680 (K1T67_10680) 2312318..2312683 + 366 WP_015503432.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K1T67_RS10685 (K1T67_10685) 2312676..2312999 + 324 WP_003145733.1 XRE family transcriptional regulator Antitoxin
K1T67_RS10690 (K1T67_10690) 2313375..2314463 - 1089 WP_003145732.1 DUF3396 domain-containing protein -
K1T67_RS10695 (K1T67_10695) 2314480..2315181 - 702 WP_023110332.1 VRR-NUC domain-containing protein -
K1T67_RS10700 (K1T67_10700) 2315178..2315696 - 519 WP_031629200.1 PAAR domain-containing protein -
K1T67_RS10705 (K1T67_10705) 2315870..2316205 - 336 WP_003140884.1 TM2 domain-containing protein -
K1T67_RS10710 (K1T67_10710) 2316448..2317086 - 639 WP_003163192.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2309895..2325002 15107


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-63)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13798.14 Da        Isoelectric Point: 4.8219

>T211966 WP_015503432.1 NZ_CP080511:2312318-2312683 [Pseudomonas aeruginosa]
VAWDIEYTDEFGDWWGSLSEDEQESLAVTVRLLEERGPSLGHPHSSGINGSRPGHMRELRTQHGGRPFRTLYAFDPRRSA
ILPIGGDKTGDDRWYELNVPIADRLHDEHLHQLREEGLIDG

Download         Length: 366 bp

>T211966 NZ_CP106886:c4794419-4793886 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11896.73 Da        Isoelectric Point: 6.4751

>AT211966 WP_003145733.1 NZ_CP080511:2312676-2312999 [Pseudomonas aeruginosa]
MAKKFSDLRAQMSPEAQARVEAKAQELLAEMPLNELRQARGLSQKMLSEVLHVQQPAIAKMERRTDMYISTLRSHIEAMG
GQLEVIARFPDGAVKISNFADIEEAGA

Download         Length: 324 bp

>AT211966 NZ_CP106886:c4794696-4794430 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References