Detailed information of TA system TA211837

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 389233..389719
• Replicon: chromosome
• Accession: NZ_CP080387
• Organism: Agrobacterium cucumeris strain O132

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: KZ699_RS01890
• Protein ID: WP_142839161.1
• Coordinates: 389233..389502 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: KZ699_RS01895
• Protein ID: WP_142839162.1
• Coordinates: 389486..389719 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZ699_RS01855 (KZ699_01845)	384327..384956	+	630	WP_142839155.1	DNA-3-methyladenine glycosylase I	-
KZ699_RS01860 (KZ699_01850)	384953..385396	+	444	WP_142839156.1	hypothetical protein	-
KZ699_RS01865 (KZ699_01855)	385407..386450	-	1044	WP_269698599.1	YeiH family protein	-
KZ699_RS01870 (KZ699_01860)	386532..387449	+	918	WP_142839158.1	LysR substrate-binding domain-containing protein	-
KZ699_RS01875 (KZ699_01865)	387583..387957	-	375	WP_142839159.1	DUF305 domain-containing protein	-
KZ699_RS01880 (KZ699_01870)	388016..388420	-	405	WP_237681340.1	hypothetical protein	-
KZ699_RS01885 (KZ699_01875)	388462..389226	-	765	WP_142839160.1	hypothetical protein	-
KZ699_RS01890 (KZ699_01880)	389233..389502	-	270	WP_142839161.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KZ699_RS01895 (KZ699_01885)	389486..389719	-	234	WP_142839162.1	DUF6290 family protein	Antitoxin
KZ699_RS01900 (KZ699_01890)	389876..391447	+	1572	WP_269698598.1	histidine--tRNA ligase	-
KZ699_RS01905 (KZ699_01895)	391457..392584	+	1128	WP_269698597.1	ATP phosphoribosyltransferase regulatory subunit	-
KZ699_RS01910 (KZ699_01900)	392581..393273	+	693	WP_142839165.1	ATP phosphoribosyltransferase	-
KZ699_RS01915 (KZ699_01905)	393338..393784	-	447	WP_142839166.1	DoxX family protein	-
KZ699_RS01920 (KZ699_01910)	393940..394374	-	435	WP_142839167.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-88)

Antitoxin

• Protein of unknown function DUF6290 (6-73)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10568.14 Da
• Isoelectric Point: 10.1371

>T211837 WP_142839161.1 NZ_CP080387:c389502-389233 [Agrobacterium cucumeris]
MTWKIEFQHRAVKQLAKLSKQDANRIVSFLADRVVQDENPRRTGTALQGSELGNYWRYRVGDYRIICDIQDHKLVVLVVE
IGHRREIYR

Nucleotide

• Length: 270 bp

>T211837 NZ_CP106786:1109221-1109631 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAGTGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 9197.25 Da
• Isoelectric Point: 4.5809

>AT211837 WP_142839162.1 NZ_CP080387:c389719-389486 [Agrobacterium cucumeris]
MSKQTAIRLPDETYERLKALSERTGRTSAYYIREAIEKHIEDMEDLYLAEEATRRQIANNERTYTLEEVMRNLDLEN

Nucleotide

• Length: 234 bp

>AT211837 NZ_CP106786:1108974-1109240 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA