Detailed information of TA system TA211584

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 595045..595586
• Replicon: chromosome
• Accession: NZ_CP080285
• Organism: Pseudomonas aeruginosa strain UNC_PaerCF14

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: KZ796_RS02850
• Protein ID: WP_219832766.1
• Coordinates: 595269..595586 (+)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q9I707
• Locus tag: KZ796_RS02845
• Protein ID: WP_003112628.1
• Coordinates: 595045..595272 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZ796_RS02820 (KZ796_02820)	590062..591555	+	1494	WP_003101230.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-
KZ796_RS02825 (KZ796_02825)	591724..593151	+	1428	WP_003083784.1	GABA permease	-
KZ796_RS02830 (KZ796_02830)	593233..593574	-	342	WP_003101229.1	zinc ribbon domain-containing protein YjdM	-
KZ796_RS02835 (KZ796_02835)	593648..594148	-	501	WP_003112629.1	LEA type 2 family protein	-
KZ796_RS02840 (KZ796_02840)	594249..594869	+	621	WP_003101226.1	hypothetical protein	-
KZ796_RS02845 (KZ796_02845)	595045..595272	+	228	WP_003112628.1	CopG family ribbon-helix-helix protein	Antitoxin
KZ796_RS02850 (KZ796_02850)	595269..595586	+	318	WP_219832766.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KZ796_RS02855 (KZ796_02855)	595851..596759	+	909	WP_003083769.1	LysR family transcriptional regulator	-
KZ796_RS02860 (KZ796_02860)	596791..597201	-	411	WP_003101225.1	aegerolysin family protein	-
KZ796_RS02865 (KZ796_02865)	597381..598116	-	736	Protein_566	GntR family transcriptional regulator	-
KZ796_RS02870 (KZ796_02870)	598217..598903	-	687	WP_219832767.1	FadR/GntR family transcriptional regulator	-
KZ796_RS02875 (KZ796_02875)	598952..600301	-	1350	WP_003142411.1	C4-dicarboxylate transporter DctA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 11829.85 Da
• Isoelectric Point: 10.4079

>T211584 WP_219832766.1 NZ_CP080285:595269-595586 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITPLKVVTRLQDVSK

Nucleotide

• Length: 318 bp

>T211584 NZ_CP104973:c2696242-2695838 [Phyllobacterium zundukense]
ATGCCCGCTGAGTTTCTTGATACCAACGTTCTGATTTATGCCTTTACCGATGATCCACGTCGCATAAGATCCCAAGAACT
TCTCGCTGAGGGTTGCACAATTGGCGTGCAGGTTTTGAACGAGTTCACCAATGTCGCTCGACGAAAACTTGGCATGGATT
GGGAGGAAATTCGCGAAGCGCTTGCGTCGATCTGCACACTCTGTCCAAAGATTGTTTCTATGGACGTCAATGTTCACGAA
GAGGCAATCGCCATTGCGGAACGGCACGGCTTTCAAATCTTCGATGCGCTGATGATTGCTTCGGCCATACTCAGCGGTTG
CGATGTTCTGTGGTCGGAGGACATGCGCGATGGCCTCGTAATCGAGAACCGATTGCGCATCGTCAATCCCTTCCGGCTCG
CTTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8568.64 Da
• Isoelectric Point: 5.5740

>AT211584 WP_003112628.1 NZ_CP080285:595045-595272 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT211584 NZ_CP104973:c2696462-2696232 [Phyllobacterium zundukense]
ATGCGTGTAGCAAAATGGGGCAATAGCCTGGCCATCCGATTGCCCGCAACGGTTGTAGACGCACTCGATCTCGAGGAGGG
CACCGAGATCGAAATCCGCGTGGCGGACGAGCGTACCTTCGAAATCGCGCACGATCGCAGTCGTGAGCGCGCGCTGGAAC
GTATCCGCGCTTTTGGGAAGAAACTTCCGCCGGATTGGAAATTCGACCGCGACGAATCCAATGCCCGCTGA

Structures

Antitoxin

• AlphaFold DB: Q9I707