Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-MW1433/-
Location 2019132..2019439 Replicon chromosome
Accession NZ_CP080251
Organism Staphylococcus aureus strain NT_611

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag KZZ50_RS09990 Protein ID WP_011447039.1
Coordinates 2019263..2019439 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name MW1433
Locus tag -
Coordinates 2019132..2019271 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZZ50_RS09950 (2014473) 2014473..2014733 + 261 WP_001791826.1 hypothetical protein -
KZZ50_RS09955 (2014786) 2014786..2015136 - 351 WP_000702262.1 complement inhibitor SCIN-A -
KZZ50_RS09960 (2015819) 2015819..2016268 + 450 WP_000727645.1 chemotaxis-inhibiting protein CHIPS -
KZZ50_RS09965 (2016363) 2016363..2016697 - 335 Protein_1929 SH3 domain-containing protein -
KZZ50_RS09970 (2017348) 2017348..2017839 - 492 WP_000920042.1 staphylokinase -
KZZ50_RS09975 (2018030) 2018030..2018785 - 756 WP_000861026.1 CHAP domain-containing protein -
KZZ50_RS09980 (2018797) 2018797..2019051 - 255 WP_000611512.1 phage holin -
KZZ50_RS09985 (2019103) 2019103..2019210 + 108 WP_031762631.1 hypothetical protein -
- (2019132) 2019132..2019271 + 140 NuclAT_0 - Antitoxin
- (2019132) 2019132..2019271 + 140 NuclAT_0 - Antitoxin
- (2019132) 2019132..2019271 + 140 NuclAT_0 - Antitoxin
- (2019132) 2019132..2019271 + 140 NuclAT_0 - Antitoxin
KZZ50_RS09990 (2019263) 2019263..2019439 - 177 WP_011447039.1 type I toxin-antitoxin system toxin PepG1 Toxin
KZZ50_RS09995 (2019642) 2019642..2020424 - 783 WP_000034846.1 staphylococcal enterotoxin type P -
KZZ50_RS10000 (2020831) 2020831..2021205 - 375 WP_000340977.1 hypothetical protein -
KZZ50_RS10005 (2021261) 2021261..2021548 - 288 WP_031865201.1 hypothetical protein -
KZZ50_RS10010 (2021594) 2021594..2021746 - 153 WP_001000058.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - scn / chp / sak / see / hlb / groEL 2014786..2068285 53499


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T211440 WP_011447039.1 NZ_CP080251:c2019439-2019263 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T211440 NZ_CP104863:4794079-4795401 [Stenotrophomonas maltophilia]
ATGGGTACGCTGCAGGTCTGGATGAATGGTGTGGAAGTCGCACTTTGGGATGATGTCCGGAACGGGTCACCCCGGTTGTC
GTATGTCAGCCAGTGGATCAGCTCGCCCCAGTCCCGACCGTTGTCGCTCTCTCTACCCCTGCTCCCAGATGGCGAGAGCC
ATCGGGGCAACGTCGTCAACGACTACTTCGATAACCTTCTTCCCGATAACGTCGCCATACGCAACCGGATCCGCGACCGG
TTCGCCACGCGCGGCAGCGATACGTTCGATCTTCTTGAAGCCATTGGACGGGATTGTGTCGGCGCAGTGCAGCTGTTGCC
GCCTGCGCATCCACCCGAAGACATCCAGCAGATCACGTGCGAGGTGTTGGACGAAGCAGGTGTCGCTACGATCCTGCGTC
AGGTGACGACAGGGAACCTGCCTGGCGCACCCAGCCGTGATGATGCATTCCGCATTTCCATCGCCGGTGCGCAGGAAAAG
ACCGGTCTTCTGCTGCATGCTGGCAAATGGTGCATTCCTACCGGCAACACACCATCCACTCACATCTTCAAGCTGCCGCT
TGGCATTGTTGGCAACATGCGGGCAGACATGCATCAGTCCGTGGAGAATGAATGGCTGTGCATGCATCTGCTTTCCGCTT
TTGATATCCCCGTGGCCGAGACGCAGATGGGCCGCTTCAACGACCAACGTGCTCTCATTGTCGAGCGGTTTGACCGTCGC
CTGTCTGCCGACCGCCGGTGGTGGCTGCGACTGCCACAGGAAGACATGTGTCAGGTCTTTGGTCTGCCGGCTGCCAGAAA
GTATGAATCCGATGGCGGCCCCGGTATCGTTCCGATCATGGATCTGCTTCGACAGTCCGAACACCCCGAGGATCGCGCGA
TCTTCTTCAAGACGCAGATTCTTTTCTGGATGCTGGCCGCAACCGACGGCCATGCCAAGAATTTCAGTGTTCACCTGGAA
GCCGGTGGACGCTTCCGCCTGACGCCCGTCTACGACGTGCTGTCGGTATATCCCATCCTCGGCAGGGGACCCAATCAACT
CGATCCACGAAACGCACAGCTCGCCATGGCCGTACATGGCAAGAACCGCCACCGGAAACTGCACCTTGTGCGACGGCGGC
ACTGGAATGAAACCGCGCGCGCCTGCGGCGTTGCCGATGGTGCAGAACCATGGATCAAGACATTGATCGCGGCCGTCGAG
CCCGCCATCCAGCAGGTCACCCGTCAGCTCCCGGATGACTTCCCCTCAAACGTGTCCGAACCGATTTTCAACGGACTTCG
TGCTGCGGCAGCACGCCTTTCCAGCATGGCCCCCGAGGCTTGA

Antitoxin


Download         Length: 140 bp

>AT211440 NZ_CP080251:2019132-2019271 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References