Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4146293..4146551 Replicon chromosome
Accession NZ_CP080246
Organism Escherichia coli strain SYNB1934

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag KZX95_RS19925 Protein ID WP_000809168.1
Coordinates 4146293..4146445 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4146494..4146551 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZX95_RS19905 4141538..4142251 - 714 WP_001102391.1 acidic protein MsyB -
KZX95_RS19910 4142277..4142681 - 405 WP_000843687.1 DUF2541 family protein -
KZX95_RS19915 4143053..4144969 + 1917 WP_000516135.1 molecular chaperone DnaK -
KZX95_RS19920 4145058..4146188 + 1131 WP_001118465.1 molecular chaperone DnaJ -
KZX95_RS19925 4146293..4146445 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 4146494..4146551 + 58 - - Antitoxin
KZX95_RS19930 4147060..4147821 + 762 WP_001274832.1 outer membrane protein OmpK -
KZX95_RS19935 4147841..4149334 + 1494 WP_001443162.1 sulfatase-like hydrolase/transferase -
KZX95_RS19940 4149463..4150722 + 1260 WP_000494928.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T211370 WP_000809168.1 NZ_CP080246:c4146445-4146293 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T211370 NZ_CP104848:c3046002-3045900 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 58 bp

>AT211370 NZ_CP080246:4146494-4146551 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References