Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4603142..4604011 Replicon chromosome
Accession NZ_CP080155
Organism Escherichia coli strain PK8261

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0U4BLW2
Locus tag KZY07_RS22220 Protein ID WP_059309235.1
Coordinates 4603601..4604011 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0X5FMN2
Locus tag KZY07_RS22215 Protein ID WP_039023579.1
Coordinates 4603142..4603510 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZY07_RS22185 (4599220) 4599220..4600104 + 885 WP_000010380.1 YfjP family GTPase -
KZY07_RS28120 (4600079) 4600079..4600210 - 132 WP_001349446.1 hypothetical protein -
KZY07_RS22190 (4600290) 4600290..4601108 + 819 WP_001234688.1 DUF932 domain-containing protein -
KZY07_RS22195 (4601190) 4601190..4601669 + 480 WP_000860074.1 antirestriction protein -
KZY07_RS22200 (4601685) 4601685..4602161 + 477 WP_001349449.1 RadC family protein -
KZY07_RS22205 (4602224) 4602224..4602445 + 222 WP_000692315.1 DUF987 domain-containing protein -
KZY07_RS27760 (4602460) 4602460..4603092 + 633 Protein_4375 antitoxin of toxin-antitoxin stability system -
KZY07_RS22215 (4603142) 4603142..4603510 + 369 WP_039023579.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KZY07_RS22220 (4603601) 4603601..4604011 + 411 WP_059309235.1 TA system toxin CbtA family protein Toxin
KZY07_RS22225 (4603974) 4603974..4604123 + 150 Protein_4378 DUF5983 family protein -
KZY07_RS22230 (4604199) 4604199..4604396 + 198 WP_085975623.1 DUF957 domain-containing protein -
KZY07_RS22235 (4604481) 4604481..4605322 + 842 Protein_4380 DUF4942 domain-containing protein -
KZY07_RS22240 (4605631) 4605631..4606815 + 1185 WP_001218742.1 tyrosine-type recombinase/integrase -
KZY07_RS22245 (4606965) 4606965..4607976 + 1012 Protein_4382 substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15234.33 Da        Isoelectric Point: 6.8522

>T211119 WP_059309235.1 NZ_CP080155:4603601-4604011 [Escherichia coli]
MKLLPDTHVREASCCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITLGSIRGRNDETFPDAGSRQH

Download         Length: 411 bp

>T211119 NZ_CP104698:3735732-3737045 [Proteus mirabilis]
ATGGCGAGTCTTGATGTATATATGAATGAATACTATGTGGGCATCTTTACTAAAAAAAGCTCAGGTGCGCATTCATTCCA
ATATACTGAAGATTGGGTTAATCAACCAGGAAGTCGTCCCATCTCTCTTTCGATGCCATTACAGCTTCAAGAATATCAAG
GAGACTGTGTCTATAATTTCTTTGATAATCTGTTACCTGATAATACTGAAATTAGAAATCGTATTGTGAGTCGCTATAAT
GCGAACTCAAATCAACCCTTTGACCTATTAGCGGCTATCGGTGCAGATACTGTTGGTGCATTAAGGTTACTTCCTAGTGG
CAGTACGCCTGCGGATATCAAAAAAATAGAATATCAAAAACTCAATGATATTGAGCTTGAAAAAATTCTACTAGGATATA
AATCCAATACTCCACTCGGTATGCTTAAAGAATATACTGATTTCAGAATTTCCATCGCTGGAGCACAAGAAAAAACAGCA
TTACTTTTAAAAGATAATCATTGGTGTGTGCCACATAATAACACACCAACTACCCATATTATTAAACTGCCAATTGGTGT
TATTGAAAGTCATTCTTATACAATGGATTTATCCAATAGTGTAGAAAATGAGTATCTTTGTACCTTAATTGCCAAAGAAT
TTGATCTTCCCGTCCCCCACTGCTCTATTATTAAAACAAAAAATGTTAAAGCGCTTGCTGTAGAACGTTTTGATAGAAAA
TATTCATCTGATAAATCGTGGATAATACGTTTACCTCAAGAAGATTTTTGCCAAATTTTAAATATACCTTCTGCGCTAAA
ATATGAAAATGAAGGAGGGCCTGGCATTATCGATATTATGAAATATTTACTTGGCTCATCAAATGCCGATCAAGATCGTT
TTCATTTTATGAAGGCACAAGTGCTATTTTGGCTTTTGGCTGCAACGGATGGACACGCAAAGAATTTTTCTGTTTTTATC
AACCAAGAAGGACGTTTCCATCTCACTCCCCTTTATGACATTATGTCCATCTATCCCAATTTCGGAGGACGAGGACTTAA
TCCACGAGATGCAAAACTTGCTATGGGATTAAAAGCAAGCCGAGGCAAAAAATACGCAATAGAACAAATTTTTCCTCGTC
ATTTCTACCAAACAGCTGAAGCTGTCGGTTTCGATCCTTCATTAATGAGCGATATTCTTCGTTATTTTTATCAAGAAATG
GACGATGTCATACAACGCGTAAAACAGCAATTACCCGAGGATTTCCCTTCTGAGATTAGCAATACAATATTAGATGGAAT
GAAAGCACGCGCTGTTAGATTAGCTAACATTTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13672.49 Da        Isoelectric Point: 6.7393

>AT211119 WP_039023579.1 NZ_CP080155:4603142-4603510 [Escherichia coli]
VSDTLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT211119 NZ_CP104698:3735474-3735731 [Proteus mirabilis]
ATGATCATAATTAATGCCTATCAACTCAGTGTGCATCTAAAAGATGTCCGATTAACAAAAAAACTGTCTCAAAGTAAAGT
CGCCCAAAAAGTAGGGATCCGACAAGATACCGTGTCCAATTTTGAACTTAATCCTAATTCCACCAAACTAGAAACCTTTT
TCAAACTGCTCTCCGCACTAAATTTAGAGATGGAAATTCATCCTAAAGATGCTAAAAATAATTTAGCACACAAAAGTGAA
TGGAAAGAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U4BLW2

Antitoxin

Source ID Structure
AlphaFold DB A0A0X5FMN2

References