Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4391706..4392541 Replicon chromosome
Accession NZ_CP080139
Organism Escherichia coli strain PK8241

Toxin (Protein)


Gene name yeeV Uniprot ID A0A7W4PV54
Locus tag KZY05_RS22065 Protein ID WP_000854821.1
Coordinates 4391706..4392083 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0D0LUA6
Locus tag KZY05_RS22070 Protein ID WP_001285613.1
Coordinates 4392173..4392541 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZY05_RS22045 (4388074) 4388074..4389612 - 1539 WP_001187177.1 lysine decarboxylation/transport transcriptional activator CadC -
KZY05_RS22050 (4390360) 4390360..4391202 - 843 WP_001280493.1 DUF4942 domain-containing protein -
KZY05_RS22055 (4391287) 4391287..4391484 - 198 WP_085949090.1 DUF957 domain-containing protein -
KZY05_RS22060 (4391512) 4391512..4391709 - 198 Protein_4344 DUF5983 family protein -
KZY05_RS22065 (4391706) 4391706..4392083 - 378 WP_000854821.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
KZY05_RS22070 (4392173) 4392173..4392541 - 369 WP_001285613.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KZY05_RS22075 (4392621) 4392621..4392842 - 222 WP_000692350.1 DUF987 domain-containing protein -
KZY05_RS22080 (4392935) 4392935..4393411 - 477 WP_001384108.1 RadC family protein -
KZY05_RS22085 (4393427) 4393427..4393909 - 483 WP_000206657.1 antirestriction protein -
KZY05_RS22090 (4394001) 4394001..4394819 - 819 WP_042634191.1 DUF932 domain-containing protein -
KZY05_RS22095 (4394909) 4394909..4395142 - 234 WP_001117568.1 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13930.95 Da        Isoelectric Point: 8.5163

>T211040 WP_000854821.1 NZ_CP080139:c4392083-4391706 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T211040 NZ_CP104665:c4499681-4499331 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13636.42 Da        Isoelectric Point: 6.0618

>AT211040 WP_001285613.1 NZ_CP080139:c4392541-4392173 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQTFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT211040 NZ_CP104665:c4499926-4499675 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W4PV54

Antitoxin

Source ID Structure
AlphaFold DB A0A0D0LUA6

References