Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2923354..2924189 Replicon chromosome
Accession NZ_CP080075
Organism Escherichia coli strain 19SZHZ663Rt

Toxin (Protein)


Gene name yeeV Uniprot ID A0A6H2GFM1
Locus tag KZO16_RS14060 Protein ID WP_065304416.1
Coordinates 2923354..2923731 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A6H2GGB7
Locus tag KZO16_RS14065 Protein ID WP_001285390.1
Coordinates 2923821..2924189 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZO16_RS14025 (2918535) 2918535..2920256 + 1722 WP_001202180.1 cysteine/glutathione ABC transporter ATP-binding protein/permease CydC -
KZO16_RS14030 (2920298) 2920298..2921002 + 705 WP_001241678.1 leucyl/phenylalanyl-tRNA--protein transferase -
KZO16_RS14035 (2921287) 2921287..2921505 + 219 WP_001040187.1 translation initiation factor IF-1 -
KZO16_RS14045 (2921996) 2921996..2922838 - 843 WP_065304417.1 DUF4942 domain-containing protein -
KZO16_RS14050 (2922935) 2922935..2923132 - 198 WP_086598277.1 DUF957 domain-containing protein -
KZO16_RS14055 (2923208) 2923208..2923357 - 150 Protein_2756 DUF5983 family protein -
KZO16_RS14060 (2923354) 2923354..2923731 - 378 WP_065304416.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
KZO16_RS14065 (2923821) 2923821..2924189 - 369 WP_001285390.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KZO16_RS14070 (2924239) 2924239..2924883 - 645 WP_065304415.1 antitoxin of toxin-antitoxin stability system -
KZO16_RS14075 (2924898) 2924898..2925119 - 222 WP_000692312.1 DUF987 domain-containing protein -
KZO16_RS14080 (2925188) 2925188..2925664 - 477 WP_001186747.1 RadC family protein -
KZO16_RS14085 (2925679) 2925679..2926164 - 486 WP_000214317.1 antirestriction protein -
KZO16_RS14090 (2926255) 2926255..2927076 - 822 WP_106668205.1 DUF932 domain-containing protein -
KZO16_RS14095 (2927297) 2927297..2927707 - 411 WP_000846713.1 hypothetical protein -
KZO16_RS14100 (2927723) 2927723..2928400 - 678 WP_059239983.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14060.06 Da        Isoelectric Point: 7.8522

>T210653 WP_065304416.1 NZ_CP080075:c2923731-2923354 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYQEAKQ

Download         Length: 378 bp

>T210653 NZ_CP104584:c4885113-4884358 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATATCCGACCGCTCCAGGGGCGCCTGGTGCGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGACACCCTGGAAGAACAGGCGTTGCTCGAGGAACTGCTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGATGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGCTGGGGG
TCGCGGTTTGGCCGTCGCCACGAGCCAAGCCTGTTCTACGCCGCGCTGAAGCTGGAAACGGCCATGGCCGAAAGCGCGTA
TTACCGTTGCGTCCTGTGGAGTGGCATGGTGGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATCCGTCTGCAGGCGCCGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTCCCCAGGAACTGGGAAGTGCCATGCGCAGCGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGTCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCCTTCAAGCCGGCGCATGTGCCGGGGTCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGGACGGAAAGTTGCCGCATCCGGCGTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13811.52 Da        Isoelectric Point: 5.9618

>AT210653 WP_001285390.1 NZ_CP080075:c2924189-2923821 [Escherichia coli]
VSDTFHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT210653 NZ_CP104584:c4885616-4885248 [Pseudomonas aeruginosa]
ATGAGCGCTCTCATCAAGGAACGTCCCAGCGCCGATGCCGTCCTGGCCAAGGCCGTCCTGGCCGCGCGCGAGCAATTGGG
GCTGACGCAGCTCGAACTGGCCGGCATCGTCGGCGTCGATCGCAGCGCCATCAGCCGCTGGAAGACCCAGGGCTTGCGGG
TGGACAGCAAGACCGGCGAGCTGGCTCTGCTGCTGGTGCGAGTCTATCGCGCACTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACATGCGCCACTTCCTGCGCACTCCCAACCATCACCTGGCGGGCGAGCCGCTGGCACTGATGGGACAGGTGCAGGG
CCTGGTTCATGTGCTGGAATACCTCGATGCGATCCGCGGCAAGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6H2GFM1

Antitoxin

Source ID Structure
AlphaFold DB A0A6H2GGB7

References