Detailed information of TA system TA210361

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): toxTA/Tad-couple_hipB
• Location: 1537150..1537795
• Replicon: chromosome
• Accession: NZ_CP079921
• Organism: Actinobacillus pleuropneumoniae strain P1875

Toxin (Protein)

• Gene name: toxT
• Uniprot ID: B0BQU7
• Locus tag: KZH40_RS07010
• Protein ID: WP_005619674.1
• Coordinates: 1537424..1537795 (-)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: KZH40_RS07005
• Protein ID: WP_005598477.1
• Coordinates: 1537150..1537443 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZH40_RS06975 (KZH40_07030)	1532482..1533165	-	684	WP_005601946.1	arginine ABC transporter permease ArtM	-
KZH40_RS06980 (KZH40_07035)	1533165..1533836	-	672	WP_005601949.1	arginine ABC transporter permease ArtQ	-
KZH40_RS06985 (KZH40_07040)	1533842..1534561	-	720	WP_005619670.1	transporter substrate-binding domain-containing protein	-
KZH40_RS06990 (KZH40_07045)	1534581..1535315	-	735	WP_005598473.1	arginine ABC transporter ATP-binding protein ArtP	-
KZH40_RS06995 (KZH40_07050)	1535540..1536037	-	498	WP_005601953.1	YbhB/YbcL family Raf kinase inhibitor-like protein	-
KZH40_RS07000 (KZH40_07055)	1536110..1537072	+	963	WP_005619672.1	calcium/sodium antiporter	-
KZH40_RS07005 (KZH40_07060)	1537150..1537443	-	294	WP_005598477.1	helix-turn-helix domain-containing protein	Antitoxin
KZH40_RS07010 (KZH40_07065)	1537424..1537795	-	372	WP_005619674.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KZH40_RS07015 (KZH40_07070)	1537989..1539740	+	1752	WP_005601957.1	protein-disulfide reductase DsbD	-
KZH40_RS07020 (KZH40_07075)	1539798..1540367	+	570	WP_005601959.1	elongation factor P hydroxylase	-
KZH40_RS07025 (KZH40_07080)	1540411..1541265	-	855	WP_005598486.1	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (32-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-85)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 15066.57 Da
• Isoelectric Point: 10.4054

>T210361 WP_005619674.1 NZ_CP079921:c1537795-1537424 [Actinobacillus pleuropneumoniae]
MYEIVFYRDKRGREPVKEFLLRLLKERQEGSRERLHKISHHLSILHLHGTRAGENYIKHLEDRIWQLRPVGDCLLFASII
RGKFVLLHYFAKQNYRIPKREIERAKVRLADLQERIKDEPYWF

Nucleotide

• Length: 372 bp

>T210361 NZ_CP104503:4009844-4010158 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10935.81 Da
• Isoelectric Point: 10.3120

>AT210361 WP_005598477.1 NZ_CP079921:c1537443-1537150 [Actinobacillus pleuropneumoniae]
MSPIGSSWTSFEQEIFDESEIAETQFRIRLILEIIETRQQLGISQRKLEKLSGVKQSMIARVEKGSVNPSLATVLKLLVP
LGKTLQIVPLDKNKTVR

Nucleotide

• Length: 294 bp

>AT210361 NZ_CP104503:4009608-4009841 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Structures

Toxin

• AlphaFold DB: A3N206