Detailed information of TA system TA210343

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 3675815..3676337
• Replicon: chromosome
• Accession: NZ_CP079891
• Organism: Escherichia fergusonii strain 5zf15-2-1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A7W3EN85
• Locus tag: KYD87_RS18110
• Protein ID: WP_046083069.1
• Coordinates: 3676047..3676337 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: KYD87_RS18105
• Protein ID: WP_223665963.1
• Coordinates: 3675815..3676057 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KYD87_RS18085 (3671730)	3671730..3673103	+	1374	WP_182210611.1	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase	-
KYD87_RS18090 (3673186)	3673186..3673737	-	552	WP_000166270.1	ribosome biogenesis factor YjgA	-
KYD87_RS18095 (3673831)	3673831..3675183	+	1353	WP_001162171.1	metalloprotease PmbA	-
KYD87_RS18100 (3675238)	3675238..3675624	+	387	WP_001232246.1	cytochrome b562	-
KYD87_RS18105 (3675815)	3675815..3676057	+	243	WP_223665963.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
KYD87_RS18110 (3676047)	3676047..3676337	+	291	WP_046083069.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KYD87_RS18115 (3676338)	3676338..3676802	-	465	WP_001106232.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
KYD87_RS18120 (3676960)	3676960..3679098	-	2139	WP_046076417.1	anaerobic ribonucleoside-triphosphate reductase	-
KYD87_RS18125 (3679492)	3679492..3681147	-	1656	WP_046082045.1	alpha,alpha-phosphotrehalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-65)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11323.22 Da
• Isoelectric Point: 10.3007

>T210343 WP_046083069.1 NZ_CP079891:3676047-3676337 [Escherichia fergusonii]
MNYELAFDPRALKEWQKLGVTVREQFKKKLGDVLKRPRNPSAKLRDLPDCYKIKLRTLGYRRVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Nucleotide

• Length: 291 bp

>T210343 NZ_CP104501:214228-215553 [Escherichia coli]
ATGAGCCGGAAACAGCAACGTCTGGTAATTTGGATGAACGGCATCAAAGTCGGGTACTGGGAAAAAAGCAAAGGGGTAGA
CAGCTTAGAATACCTTCCTGAATGGGTTGCTGACGAACAGGGAAGGCCGCTGTCATTGTCCCTTCCTTTTACTCCCGGGA
ACCAGGTCTGGCGTGGAAATGTGGTACGTGACTATTTTGATAATTTACTGCCGGACAGCGAAGGCATACGCAGACGTCTG
GCAATGCGTTACAAGGCCGATAGCCTGGAGCCTTTTGATCTGCTGACGGAGCTGGGAAAAGACTGCGTGGGCGCGATACA
GCTGCTTCATGACGGAGATGAACCCACTGATTTATATTCCGTGAAGTATCACCCGCTTACTGAATCAGAAATTGCGGCAA
CTTTGCGTAATACCACGGAGACATTGCTACCGGGCAGGCCAGAAGATAACGACGACTTACGTTTATCTATTGCCGGTGCT
CAGGAGAAAACAGCCCTACTGTGGCATGAAGATCGGTGGTGTATGCCGGAGGGTAATACACCAACGACGCATATATTCAA
GCTACCGCTCGGACTTGTGGGGAACATGAAAGCCGACATGAGCTCGTCGGTTGAAAATGAATGGCTCTGCTCGGTACTTC
TCGGCCAGTACGGGCTCCCCGTGGCAAGAACGCAGATTGCTCACTTTGAAGATCAGAAAGCGCTGGTGGTAGAACGTTTT
GACCGAAAATGGTCAGGAGACGGACAATGGATCATTCGTTTACCCCAGGAGGATATGTGTCAGGCCCTGGGCGTTTCGCC
ATTACGAAAATATCAGGCGGACGGCGGGCCAGGTATATCGGAAATTATGGAGGTTCTGAGTAATTCAGACCGTGCTGAGC
GTGACAAAGCGCAGTTTTTTATGACGCAGATAATTTTCTGGATGATGGCCGCAACAGATGGCCACGCTAAAAATTTCAGT
ATTTCTATTGGGCCACAGGGACGTTATCACCTTACACCAAACTATGATGTGTTGTCGGCATGGCCGGTGATCGGTCATGG
GAACAATCAGATATCCTGGCAGAAGTGCAAACTGGCGATGGCCGTACGTGGCAGTAGCAACTATTACCAGATATATCGAA
TACAACGACGCCACTGGATCAGGCATGGTGAGATAACCGGCCTGAGTAAACAGCAGACAGAGGCGATGATAGAGGAAATC
ATCGCCAGAACCCCGGGTGTCATTGAACGTGTTAGCGGGCTTCTTCCGGACCAGTTCCCCCAGCAGCTTGCGGAAAGTAT
TTTTGATGGAATGAGGCAGCAATGCAGGCGCCTGGCTGAGAAATGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9139.58 Da
• Isoelectric Point: 5.1369

>AT210343 WP_223665963.1 NZ_CP079891:3675815-3676057 [Escherichia fergusonii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYIAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Nucleotide

• Length: 243 bp

>AT210343 NZ_CP104501:213930-214223 [Escherichia coli]
ATCAATAATGATTACCCGTTAAACACGCTCAACCAGCTGCGTCCCTTGCTCATTGGTTTTCGCAAGGCGAATGGCCTGAC
GCAAAAAGACCTGTCCGAAAGGTTAGGCGTCACTCAACAGACATACTCACGTCTGGAAGCCAACCCTGCCAGTGCGAGCA
TTGAACGGCTATTCAAGGTGTTTTCCATCCTGGGCGTAAAAATCAGCTTCTCCTCGGCAACCACCTCTTCAGAGAGGAAG
CAGACGGAAGAAATGCTTAAATCAAACTCACCTGCACGACAGGAGGATTGGTAA

Structures

Toxin

• AlphaFold DB: A0A7W3EN85