Detailed information of TA system TA210341

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2910721..2910978
• Replicon: chromosome
• Accession: NZ_CP079891
• Organism: Escherichia fergusonii strain 5zf15-2-1

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: F4T5C6
• Locus tag: KYD87_RS14510
• Protein ID: WP_001135731.1
• Coordinates: 2910721..2910873 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	2910930..2910978 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KYD87_RS14480	2906585..2907295	-	711	WP_000190514.1	DUF3053 domain-containing protein	-
KYD87_RS14485	2907733..2909103	+	1371	WP_000184983.1	MFS transporter	-
KYD87_RS14490	2909353..2909643	+	291	WP_223665912.1	HTH-type transcriptional regulator	-
KYD87_RS14495	2909925..2910137	+	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
KYD87_RS14500	2910191..2910562	-	372	WP_001037803.1	membrane protein insertion efficiency factor YidD	-
KYD87_RS14505	2910673..2910744	+	72	WP_216665726.1	hypothetical protein	-
KYD87_RS14510	2910721..2910873	-	153	WP_001135731.1	type I toxin-antitoxin system toxin HokA	Toxin
-	2910930..2910978	+	49	-	-	Antitoxin
KYD87_RS14515	2911173..2911532	-	360	WP_141095883.1	hypothetical protein	-
KYD87_RS14520	2911601..2913670	-	2070	WP_001291786.1	glycine--tRNA ligase subunit beta	-
KYD87_RS14525	2913680..2914591	-	912	WP_001168544.1	glycine--tRNA ligase subunit alpha	-
KYD87_RS14530	2914687..2914986	-	300	WP_024256552.1	YsaB family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (5-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 6025.30 Da
• Isoelectric Point: 7.7169

>T210341 WP_001135731.1 NZ_CP079891:c2910873-2910721 [Escherichia fergusonii]
MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIKQENYELAAFLACKLKE

Nucleotide

• Length: 153 bp

>T210341 NZ_CP104501:125070-125357 [Escherichia coli]
ATGAGGTATCAGGTAAAATTCAGGGAAGATGCGCTGAAAGAGTGGCAAAAACTGGACAAGACTATTCAGCAACAGTTTGC
GAAAAAGCTAAAAAAGTGCTGTGACAATCCGCATATTCCTTCCGCAAAACTGCGCGGGATAAAGGACTGCTACAAAATAA
AATTACGTGCGTCAGGTTTACGCCTGGTCTATCAGGTGATTGACGAACAATTAATTATCGCTGTTGTAGCAGTGGGTAAA
CGTGAGCGCAGTGACGTTTATAATCTTGCCAGTGAAAGAATGAGATAA

Antitoxin

Nucleotide

• Length: 49 bp

>AT210341 NZ_CP079891:2910930-2910978 [Escherichia fergusonii]
GCATAGAGGGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Toxin

• AlphaFold DB: A0A061YDD9

Antitoxin