Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 37193..37836 | Replicon | plasmid p1-6S41-1 |
| Accession | NZ_CP079885 | ||
| Organism | Escherichia fergusonii strain 6S41-1 | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | A0A6H2GRP8 |
| Locus tag | KYC43_RS23270 | Protein ID | WP_023292131.1 |
| Coordinates | 37193..37609 (-) | Length | 139 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | - |
| Locus tag | KYC43_RS23275 | Protein ID | WP_223672110.1 |
| Coordinates | 37606..37836 (-) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KYC43_RS23225 (32543) | 32543..32851 | + | 309 | Protein_33 | integrase core domain-containing protein | - |
| KYC43_RS23230 (32881) | 32881..33090 | - | 210 | WP_094308932.1 | hypothetical protein | - |
| KYC43_RS23235 (33139) | 33139..33342 | - | 204 | WP_004150739.1 | HHA domain-containing protein | - |
| KYC43_RS23240 (33403) | 33403..33897 | - | 495 | WP_094313750.1 | DNA-binding protein | - |
| KYC43_RS23245 (33928) | 33928..34500 | - | 573 | WP_223672109.1 | hypothetical protein | - |
| KYC43_RS23250 (34505) | 34505..34753 | - | 249 | WP_065801593.1 | hypothetical protein | - |
| KYC43_RS23255 (35032) | 35032..36038 | - | 1007 | Protein_39 | IS110 family transposase | - |
| KYC43_RS23260 (36595) | 36595..36849 | - | 255 | WP_095153353.1 | hypothetical protein | - |
| KYC43_RS23265 (36913) | 36913..37158 | - | 246 | WP_065801591.1 | hypothetical protein | - |
| KYC43_RS23270 (37193) | 37193..37609 | - | 417 | WP_023292131.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| KYC43_RS23275 (37606) | 37606..37836 | - | 231 | WP_223672110.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| KYC43_RS23280 (38155) | 38155..38415 | + | 261 | WP_032280099.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| KYC43_RS23285 (38441) | 38441..38698 | + | 258 | WP_199802185.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| KYC43_RS23290 (38860) | 38860..39801 | - | 942 | WP_058820814.1 | hypothetical protein | - |
| KYC43_RS23295 (40036) | 40036..41436 | - | 1401 | WP_223672111.1 | ISNCY family transposase | - |
| KYC43_RS23300 (41713) | 41713..42138 | + | 426 | WP_000422741.1 | transposase | - |
| KYC43_RS23305 (42135) | 42135..42485 | + | 351 | WP_000624722.1 | IS66 family insertion sequence element accessory protein TnpB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | espP / vat / cseA | 1..118628 | 118628 | |
| - | inside | IScluster/Tn | - | cseA | 18904..46201 | 27297 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 14975.40 Da Isoelectric Point: 8.5464
>T210312 WP_023292131.1 NZ_CP079885:c37609-37193 [Escherichia fergusonii]
VKKTFMLDTNICSFIMREQPAAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHIELVDAFCARLDAILPWDRA
AVDATTEIKVALRQAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLVLEDWVN
VKKTFMLDTNICSFIMREQPAAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHIELVDAFCARLDAILPWDRA
AVDATTEIKVALRQAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLVLEDWVN
Download Length: 417 bp
>T210312 NZ_CP104496:c315306-314893 [Ralstonia pseudosolanacearum]
ATGCCCGCGACTGAGGCATTCTTCGACAGCAATGTCGTGCTGTACCTGCTGTCGGCCGACACCGCCAAGGCCGATGCGGC
GGAAACGCTGCTGATGACCGGCGGTGTCGTCAGCGTACAGGTACTGAACGAAACGACGCACGTGATGCGCCGCAAGCTGG
CCATGCCGTGGCACGCGATCGAAACGGTGCAGGAGGCCGTGCGTGCGCAATGCCGGGTCGAGCCGCTGACGCTCGAAACC
CATGATCTCGGACGGCGTATCGCAGAACGCTACGGATTGTCGGTCTATGACGCACTGATCGTCGCGGCGGCATTGCTTGC
CGGCTGCAACGTTCTGTATTCCGAGGATATGCAGCACGGCCTGGTGATCGAGCAGCATCTGCGCATCGTCAATCCTTTTC
CGGCACGGGCATGA
ATGCCCGCGACTGAGGCATTCTTCGACAGCAATGTCGTGCTGTACCTGCTGTCGGCCGACACCGCCAAGGCCGATGCGGC
GGAAACGCTGCTGATGACCGGCGGTGTCGTCAGCGTACAGGTACTGAACGAAACGACGCACGTGATGCGCCGCAAGCTGG
CCATGCCGTGGCACGCGATCGAAACGGTGCAGGAGGCCGTGCGTGCGCAATGCCGGGTCGAGCCGCTGACGCTCGAAACC
CATGATCTCGGACGGCGTATCGCAGAACGCTACGGATTGTCGGTCTATGACGCACTGATCGTCGCGGCGGCATTGCTTGC
CGGCTGCAACGTTCTGTATTCCGAGGATATGCAGCACGGCCTGGTGATCGAGCAGCATCTGCGCATCGTCAATCCTTTTC
CGGCACGGGCATGA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8771.85 Da Isoelectric Point: 4.4432
>AT210312 WP_223672110.1 NZ_CP079885:c37836-37606 [Escherichia fergusonii]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRAYPDFMAEREDVVSDEGRFDL
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRAYPDFMAEREDVVSDEGRFDL
Download Length: 231 bp
>AT210312 NZ_CP104496:c315526-315293 [Ralstonia pseudosolanacearum]
ATGCAAGTCTCGAAATGGGGCAACAGCCTCGCTATCCGGCTGCCGGCGGCCGTTGTGGAGGCGCTTCAGCTGCACGAAGG
CGACGACGTCGAGGTGGTGATCGCGGGCGAGCGCTCGTTTGGCGTCCGCCGCAAGCGCGCTGCGCGCGAGCTTTTCGACC
GGATCCACCAATATCGCGGCAAGCTGCCCGCCGATTTCATCTTCGAGCGCGACCAGGCCAATGCCCGCGACTGA
ATGCAAGTCTCGAAATGGGGCAACAGCCTCGCTATCCGGCTGCCGGCGGCCGTTGTGGAGGCGCTTCAGCTGCACGAAGG
CGACGACGTCGAGGTGGTGATCGCGGGCGAGCGCTCGTTTGGCGTCCGCCGCAAGCGCGCTGCGCGCGAGCTTTTCGACC
GGATCCACCAATATCGCGGCAAGCTGCCCGCCGATTTCATCTTCGAGCGCGACCAGGCCAATGCCCGCGACTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|